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Socs5 suppressor of cytokine signaling 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500616, updated on 11-Apr-2024

Summary

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Official Symbol
Socs5provided by RGD
Official Full Name
suppressor of cytokine signaling 5provided by RGD
Primary source
RGD:1564914
See related
Ensembl:ENSRNOG00000028504 AllianceGenome:RGD:1564914
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564914
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity; epidermal growth factor receptor binding activity; and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including cellular response to low-density lipoprotein particle stimulus; negative regulation of macromolecule metabolic process; and regulation of T-helper cell differentiation. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Predicted to be part of phosphatidylinositol 3-kinase complex. Orthologous to human SOCS5 (suppressor of cytokine signaling 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 134.4), Kidney (RPKM 114.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Socs5 in Genome Data Viewer
Location:
6q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (13235157..13266161, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (7481039..7512644, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (10671311..10705610)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103467 Neighboring gene uncharacterized LOC134479309 Neighboring gene uncharacterized LOC134479310 Neighboring gene karyopherin subunit alpha 2 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in rat brain astrocytes. Hwang MN, et al. Mol Cells, 2007 Feb 28. PMID 17464217
  2. [Expression of suppressor of cytokine signaling in retina of experimental autoimmune uveoretinitis]. Wang H, et al. Zhonghua Yan Ke Za Zhi, 2008 Oct. PMID 19176113
  3. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. Kario E, et al. J Biol Chem, 2005 Feb 25. PMID 15590694
  4. Inhibitors of cytokine signal transduction. Wormald S, et al. J Biol Chem, 2004 Jan 9. PMID 14607831
  5. Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Nicholson SE, et al. Proc Natl Acad Sci U S A, 2005 Feb 15. PMID 15695332, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that activated Stat3 binds to SOCS promoters and leads to their transcriptional induction.
    Title: PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in rat brain astrocytes.
  2. Up-regulation of SOCS5 may have protective functions in experimental autoimmune uveoretinitis.
    Title: [Expression of suppressor of cytokine signaling in retina of experimental autoimmune uveoretinitis].
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T-helper 1 cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in vascular endothelial cell response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
suppressor of cytokine signaling 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109274.1 → NP_001102744.1  suppressor of cytokine signaling 5

    See identical proteins and their annotated locations for NP_001102744.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A6H9E6, D3ZUE4
    Related
    ENSRNOP00000020346.3, ENSRNOT00000020337.5
    Conserved Domains (3) summary
    cd03739
    Location:479 → 534
    SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
    pfam12610
    Location:146 → 195
    SOCS; Suppressor of cytokine signalling
    cl15255
    Location:370 → 470
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    13235157..13266161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239718.5 → XP_006239780.1  suppressor of cytokine signaling 5 isoform X1

    See identical proteins and their annotated locations for XP_006239780.1

    UniProtKB/TrEMBL
    A6H9E6, D3ZUE4
    Related
    ENSRNOP00000087303.1
    Conserved Domains (3) summary
    cd03739
    Location:479 → 534
    SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
    pfam12610
    Location:146 → 195
    SOCS; Suppressor of cytokine signalling
    cl15255
    Location:370 → 470
    SH2; Src homology 2 (SH2) domain

  2. XM_063262285.1 → XP_063118355.1  suppressor of cytokine signaling 5 isoform X1

    UniProtKB/TrEMBL
    A6H9E6, D3ZUE4

  3. XM_063262286.1 → XP_063118356.1  suppressor of cytokine signaling 5 isoform X1

    UniProtKB/TrEMBL
    A6H9E6, D3ZUE4
Nucleotide Protein Strain
Heading Accession and Version

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