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Rad51b RAD51 paralog B [ Rattus norvegicus (Norway rat) ]

Gene ID: 500679, updated on 30-Mar-2024

Summary

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Official Symbol
Rad51bprovided by RGD
Official Full Name
RAD51 paralog Bprovided by RGD
Primary source
RGD:1560681
See related
Ensembl:ENSRNOG00000059245 AllianceGenome:RGD:1560681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rad51l1; RGD1560681
Summary
Predicted to enable ATP-dependent activity, acting on DNA; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination and positive regulation of G2/M transition of mitotic cell cycle. Predicted to act upstream of or within blastocyst growth; positive regulation of cell population proliferation; and somite development. Predicted to be located in replication fork. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Orthologous to human RAD51B (RAD51 paralog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 27.8), Spleen (RPKM 18.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (103829390..104373923)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (98096525..98640988)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (102473978..103018185)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene zinc finger FYVE-type containing 26 Neighboring gene retinol dehydrogenase 12 Neighboring gene centrin 2 like 1 Neighboring gene uncharacterized LOC134479407 Neighboring gene uncharacterized LOC134479408 Neighboring gene uncharacterized LOC134479406 Neighboring gene uncharacterized LOC102546647 Neighboring gene ATP synthase peripheral stalk subunit d like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Holliday junction binding activity of the human Rad51B protein. Yokoyama H, et al. J Biol Chem, 2003 Jan 24. PMID 12441335
  2. Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can Be partially rescued in a p53(-/-) background. Shu Z, et al. Mol Cell Biol, 1999 Dec. PMID 10567591, Free PMC Article
  3. The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy. Rodrigue A, et al. J Cell Sci, 2013 Jan 1. PMID 23108668
  4. Identification and purification of two distinct complexes containing the five RAD51 paralogs. Masson JY, et al. Genes Dev, 2001 Dec 15. PMID 11751635, Free PMC Article
  5. Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy. Compton SA, et al. J Biol Chem, 2010 Apr 30. PMID 20207730, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blastocyst growth ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somite development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex ISO
Inferred from Sequence Orthology
more info
  
located_in replication fork ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA repair protein RAD51 homolog 2
Names
RAD51 homolog B
RAD51-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399175.1 → NP_001386104.1  DNA repair protein RAD51 homolog 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5ZYE0
    Related
    ENSRNOP00000084086.1, ENSRNOT00000105193.1
    Conserved Domains (1) summary
    cd19493
    Location:91 → 327
    Rad51B; RAD51B recombinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    103829390..104373923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594476.3 → XP_017449965.1  DNA repair protein RAD51 homolog 2 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JTF1, A6HCH4

  2. XM_039113282.2 → XP_038969210.1  DNA repair protein RAD51 homolog 2 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JTF1, A6HCH4
    Related
    ENSRNOP00000068685.2
    Conserved Domains (1) summary
    cl38936
    Location:91 → 267
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_039113283.2 → XP_038969211.1  DNA repair protein RAD51 homolog 2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JTF1, A6HCH4
    Conserved Domains (1) summary
    cl38936
    Location:91 → 252
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_017594475.3 → XP_017449964.1  DNA repair protein RAD51 homolog 2 isoform X4

    UniProtKB/TrEMBL
    A6HCH3
    Conserved Domains (1) summary
    cd01123
    Location:83 → 277
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

  5. XM_039113281.2 → XP_038969209.1  DNA repair protein RAD51 homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AFI5
    Related
    ENSRNOP00000091401.1
    Conserved Domains (1) summary
    cd19493
    Location:67 → 288
    Rad51B; RAD51B recombinase

  6. XM_039113277.2 → XP_038969205.1  DNA repair protein RAD51 homolog 2 isoform X1

    Conserved Domains (1) summary
    cd19493
    Location:91 → 327
    Rad51B; RAD51B recombinase

  7. XM_039113279.2 → XP_038969207.1  DNA repair protein RAD51 homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYE0
    Conserved Domains (1) summary
    cd19493
    Location:91 → 327
    Rad51B; RAD51B recombinase

  8. XM_063262317.1 → XP_063118387.1  DNA repair protein RAD51 homolog 2 isoform X7

  9. XM_039113278.2 → XP_038969206.1  DNA repair protein RAD51 homolog 2 isoform X1

    Conserved Domains (1) summary
    cd19493
    Location:91 → 327
    Rad51B; RAD51B recombinase

RNA

  1. XR_010052147.1 RNA Sequence

  2. XR_005506073.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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