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Cactin cactin, spliceosome C complex subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 500790, updated on 5-Mar-2024

Summary

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Official Symbol
Cactinprovided by RGD
Official Full Name
cactin, spliceosome C complex subunitprovided by RGD
Primary source
RGD:1563634
See related
Ensembl:ENSRNOG00000039852 AllianceGenome:RGD:1563634
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563634
Summary
Predicted to be involved in several processes, including cellular response to cytokine stimulus; negative regulation of cytokine production; and negative regulation of signal transduction. Predicted to be located in cytosol and nuclear speck. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytoplasm. Orthologous to human CACTIN (cactin, spliceosome C complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 56.6), Lung (RPKM 33.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9042125..9047807, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8391396..8397219, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11258526..11266509, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene GIPC PDZ domain containing family, member 3 Neighboring gene thromboxane A2 receptor Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Neighboring gene tight junction protein 3 Neighboring gene amyloid beta precursor protein binding family A member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin. Suzuki M, et al. Cell Mol Life Sci, 2016 Mar. PMID 26363554
  2. Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways. Atzei P, et al. J Biol Chem, 2010 Nov 19. PMID 20829348, Free PMC Article
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
  4. Large-scale characterization of HeLa cell nuclear phosphoproteins. Beausoleil SA, et al. Proc Natl Acad Sci U S A, 2004 Aug 17. PMID 15302935, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
splicing factor Cactin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081447.1 → NP_001074916.1  splicing factor Cactin

    See identical proteins and their annotated locations for NP_001074916.1

    Status: PROVISIONAL

    Source sequence(s)
    AY934505
    UniProtKB/TrEMBL
    A0A8I5Y601, A1L014
    Related
    ENSRNOP00000077177.1, ENSRNOT00000117213.1
    Conserved Domains (2) summary
    pfam09732
    Location:639 → 763
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
    pfam10312
    Location:286 → 471
    Cactin_mid; Conserved mid region of cactin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9042125..9047807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079732.2 → XP_038935660.1  splicing factor Cactin isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y601, B2GUU0
    Related
    ENSRNOP00000027926.6
    Conserved Domains (2) summary
    pfam09732
    Location:640 → 764
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
    pfam10312
    Location:287 → 474
    Cactin_mid; Conserved mid region of cactin
Nucleotide Protein Strain
Heading Accession and Version

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