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Galnt4 polypeptide N-acetylgalactosaminyltransferase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500826, updated on 11-Apr-2024

Summary

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Official Symbol
Galnt4provided by RGD
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 4provided by RGD
Primary source
RGD:1564589
See related
AllianceGenome:RGD:1564589
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable manganese ion binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in perinuclear region of cytoplasm. Predicted to colocalize with Golgi apparatus. Orthologous to human GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 52.4), Liver (RPKM 49.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Galnt4 in Genome Data Viewer
Location:
7q13
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (35811904..35814445)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (33925229..33927770)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (41305437..41309621)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479668 Neighboring gene uncharacterized LOC134479669 Neighboring gene G protein subunit gamma 5, pseudogene 2 Neighboring gene POC1 centriolar protein B Neighboring gene uncharacterized LOC120093569 Neighboring gene dual specificity phosphatase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. de Las Rivas M, et al. Nat Commun, 2017 Dec 5. PMID 29208955, Free PMC Article
  2. Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. Bennett EP, et al. J Biol Chem, 1998 Nov 13. PMID 9804815
  3. The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. Argüeso P, et al. Invest Ophthalmol Vis Sci, 2003 Jan. PMID 12506059
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC125173

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 4
Names
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
polypeptide GalNAc transferase-T4
NP_001020224.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025053.2 → NP_001020224.2  polypeptide N-acetylgalactosaminyltransferase 4

    See identical proteins and their annotated locations for NP_001020224.2

    Status: PROVISIONAL

    Source sequence(s)
    BC105818
    UniProtKB/TrEMBL
    Q3KR95, Q58A68
    Conserved Domains (4) summary
    cd02510
    Location:138 → 432
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:133 → 430
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:446 → 576
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:446 → 574
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    35811904..35814445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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