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Cyth4 cytohesin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500906, updated on 13-Apr-2024

Summary

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Official Symbol
Cyth4provided by RGD
Official Full Name
cytohesin 4provided by RGD
Primary source
RGD:1564842
See related
Ensembl:ENSRNOG00000007679 AllianceGenome:RGD:1564842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pscd4; RGD1564842
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Predicted to be located in several cellular components, including centriolar satellite; cytosol; and intercellular bridge. Orthologous to human CYTH4 (cytohesin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 283.2), Thymus (RPKM 77.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112032711..112057204)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110152232..110176726)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119820521..119845003)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479753 Neighboring gene uncharacterized LOC103692944 Neighboring gene Rac family small GTPase 2 Neighboring gene uncharacterized LOC134479754 Neighboring gene uncharacterized LOC102549375 Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. Ogasawara M, et al. J Biol Chem, 2000 Feb 4. PMID 10652308
  2. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Hofmann I, et al. Curr Biol, 2007 Apr 17. PMID 17398095
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytohesin-4
Names
pleckstrin homology, Sec7 and coiled/coil domains 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130577.2 → NP_001124049.1  cytohesin-4 isoform 2

    See identical proteins and their annotated locations for NP_001124049.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HSL5, D3ZHR6
    Related
    ENSRNOP00000053065.2, ENSRNOT00000056221.3
    Conserved Domains (3) summary
    cd01252
    Location:235 → 353
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam00169
    Location:239 → 351
    PH; PH domain
    pfam01369
    Location:38 → 220
    Sec7; Sec7 domain

  2. NM_001414977.1 → NP_001401906.1  cytohesin-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HSL4
    Related
    ENSRNOP00000076651.1, ENSRNOT00000105447.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112032711..112057204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079763.2 → XP_038935691.1  cytohesin-4 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K0A0
    Related
    ENSRNOP00000071361.2
    Conserved Domains (2) summary
    cd01252
    Location:261 → 379
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:61 → 246
    Sec7; Sec7 domain

  2. XM_063264137.1 → XP_063120207.1  cytohesin-4 isoform X1

  3. XM_017595057.3 → XP_017450546.1  cytohesin-4 isoform X2

  4. XM_063264138.1 → XP_063120208.1  cytohesin-4 isoform X4

  5. XM_063264139.1 → XP_063120209.1  cytohesin-4 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZK46

  6. XM_063264140.1 → XP_063120210.1  cytohesin-4 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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