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Serhl2 serine hydrolase-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500911, updated on 30-Mar-2024

Summary

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Official Symbol
Serhl2provided by RGD
Official Full Name
serine hydrolase-like 2provided by RGD
Primary source
RGD:1563386
See related
Ensembl:ENSRNOG00000022932 AllianceGenome:RGD:1563386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563386
Summary
Predicted to enable hydrolase activity. Predicted to be located in cytoplasmic vesicle. Orthologous to several human genes including SERHL2 (serine hydrolase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 175.5), Heart (RPKM 175.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Serhl2 in Genome Data Viewer
Location:
7q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116126085..116146345)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114246035..114266298)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123963381..123990103)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NFAT activating protein with ITAM motif 1 Neighboring gene uncharacterized LOC103692952 Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene DNA polymerase delta interacting protein 3 Neighboring gene RNA, U12 small nuclear

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo. Sadusky TJ, et al. Genomics, 2001 Apr 1. PMID 11352564
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine hydrolase-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130579.2 → NP_001124051.1  serine hydrolase-like protein 2

    See identical proteins and their annotated locations for NP_001124051.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HT81, D4A071
    Related
    ENSRNOP00000028962.3, ENSRNOT00000036586.4
    Conserved Domains (2) summary
    COG0596
    Location:15 → 302
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:28 → 137
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    116126085..116146345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765775.4 → XP_008763997.1  serine hydrolase-like protein 2 isoform X1

    Conserved Domains (2) summary
    COG0596
    Location:33 → 320
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:46 → 155
    Abhydrolase_5; Alpha/beta hydrolase family

  2. XM_039079766.2 → XP_038935694.1  serine hydrolase-like protein 2 isoform X2

    Conserved Domains (1) summary
    COG0596
    Location:33 → 163
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RNA

  1. XR_010053032.1 RNA Sequence

  2. XR_010053031.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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