Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdk5r2provided by RGD
Official Full Name: cyclin-dependent kinase 5 regulatory subunit 2provided by RGD
Primary source: RGD:1562530
See related: Ensembl:ENSRNOG00000037793 AllianceGenome:RGD:1562530
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562530
Summary: Predicted to enable actin binding activity and cyclin-dependent protein serine/threonine kinase activator activity. Predicted to act upstream of or within nervous system development; positive regulation of calcium ion-dependent exocytosis; and positive regulation of protein kinase activity. Located in cytoplasm; growth cone; and membrane. Orthologous to human CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (83864922..83866390)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (76416251..76417719)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (82120059..82121527)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

yeast two-hybrid screening identified an interaction between p39 and non-muscle myosin essential light chain (MLC(17)).
Title: The CDK5 activator, p39, binds specifically to myosin essential light chain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebellum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within layer formation in cerebral cortex	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within superior olivary nucleus maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
part_of protein kinase 5 complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-dependent kinase 5 activator 2

Names: cyclin-dependent kinase 5, regulatory subunit 2 (p39)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.