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Ranbp3 RAN binding protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501281, updated on 3-Apr-2024

Summary

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Official Symbol
Ranbp3provided by RGD
Official Full Name
RAN binding protein 3provided by RGD
Primary source
RGD:1589604
See related
Ensembl:ENSRNOG00000049785 AllianceGenome:RGD:1589604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable R-SMAD binding activity and small GTPase binding activity. Predicted to contribute to GTPase activator activity. Predicted to be involved in protein export from nucleus. Predicted to be located in nucleoplasm. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Orthologous to human RANBP3 (RAN binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 141.7), Spleen (RPKM 125.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ranbp3 in Genome Data Viewer
Location:
9q11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1594344..1631587)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1507233..1544460)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10344190..10381415, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 Neighboring gene lon peptidase 1, mitochondrial Neighboring gene cation channel sperm associated auxiliary subunit delta Neighboring gene calcyphosine Neighboring gene NADH:ubiquinone oxidoreductase subunit A11 Neighboring gene vimentin-type intermediate filament associated coiled-coil protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human RanBP3, a group of nuclear RanGTP binding proteins. Mueller L, et al. FEBS Lett, 1998 May 15. PMID 9637251
  2. Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling. Dai F, et al. Dev Cell, 2009 Mar. PMID 19289081, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ran-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399356.1 → NP_001386285.1  ran-binding protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    Related
    ENSRNOP00000081158.1, ENSRNOT00000117671.1
    Conserved Domains (1) summary
    cd13180
    Location:317 → 432
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    1594344..1631587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244358.5 → XP_006244420.1  ran-binding protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006244420.1

    UniProtKB/TrEMBL
    A0A8I5ZVI9, A6KQV8, M0RD63
    Related
    ENSRNOP00000067560.3
    Conserved Domains (1) summary
    cd13180
    Location:384 → 499
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  2. XM_063267656.1 → XP_063123726.1  ran-binding protein 3 isoform X8

  3. XM_039084331.2 → XP_038940259.1  ran-binding protein 3 isoform X6

    Conserved Domains (1) summary
    cl17171
    Location:393 → 443
    PH-like; Pleckstrin homology-like domain

  4. XM_006244357.5 → XP_006244419.1  ran-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006244419.1

    UniProtKB/TrEMBL
    A0A8I5ZVI9
    Conserved Domains (1) summary
    cd13180
    Location:393 → 508
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  5. XM_006244359.5 → XP_006244421.1  ran-binding protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006244421.1

    UniProtKB/TrEMBL
    A0A8I5ZVI9, M0R920
    Related
    ENSRNOP00000065980.3
    Conserved Domains (1) summary
    cd13180
    Location:331 → 446
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  6. XM_006244360.5 → XP_006244422.1  ran-binding protein 3 isoform X4

    See identical proteins and their annotated locations for XP_006244422.1

    UniProtKB/TrEMBL
    A0A8I5ZS95, M0R5Q3
    Related
    ENSRNOP00000064728.3
    Conserved Domains (1) summary
    cd13180
    Location:326 → 441
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  7. XM_006244362.5 → XP_006244424.1  ran-binding protein 3 isoform X7

    See identical proteins and their annotated locations for XP_006244424.1

    UniProtKB/TrEMBL
    A0A8I5ZS95, A6KQV7
    Conserved Domains (1) summary
    cd13180
    Location:264 → 379
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  8. XM_039084332.2 → XP_038940260.1  ran-binding protein 3 isoform X9

    UniProtKB/TrEMBL
    A6KQV9, A6KQW1
    Conserved Domains (1) summary
    cd13180
    Location:192 → 307
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  9. XM_039084330.2 → XP_038940258.1  ran-binding protein 3 isoform X5

    UniProtKB/TrEMBL
    A6KQV9
    Conserved Domains (1) summary
    cd13180
    Location:278 → 393
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
Nucleotide Protein Strain
Heading Accession and Version

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