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Slc2a9 solute carrier family 2 member 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501925, updated on 25-Apr-2024

Summary

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Official Symbol
Slc2a9provided by RGD
Official Full Name
solute carrier family 2 member 9provided by RGD
Primary source
RGD:1597012
See related
Ensembl:ENSRNOG00000005302 AllianceGenome:RGD:1597012
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable glucose transmembrane transporter activity and urate transmembrane transporter activity. Predicted to be involved in urate metabolic process and urate transport. Predicted to act upstream of or within glucose transmembrane transport. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and nuclear envelope. Predicted to be integral component of plasma membrane. Orthologous to human SLC2A9 (solute carrier family 2 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 126.4), Kidney (RPKM 45.6) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc2a9 in Genome Data Viewer
Location:
14q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (76540649..76674277)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (72328334..72461981)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (77067537..77192702)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich splicing factor 3 pseudogene Neighboring gene uncharacterized LOC134481771 Neighboring gene WD repeat domain 1 Neighboring gene dopamine receptor D5 Neighboring gene otopetrin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. DeBosch BJ, et al. Nat Commun, 2014 Aug 7. PMID 25100214, Free PMC Article
  2. Mouse GLUT9: evidences for a urate uniporter. Bibert S, et al. Am J Physiol Renal Physiol, 2009 Sep. PMID 19587147
  3. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Vitart V, et al. Nat Genet, 2008 Apr. PMID 18327257
  4. GLUT9 is differentially expressed and targeted in the preimplantation embryo. Carayannopoulos MO, et al. Endocrinology, 2004 Mar. PMID 14657010
  5. Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9. Arakawa H, et al. Biol Pharm Bull, 2020. PMID 33132325

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9.
    Title: Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables fructose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables fructose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables hexose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT involved_in fructose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in fructose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in urate transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 9
Names
solute carrier family 2 (facilitated glucose transporter), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191551.1 → NP_001178480.1  solute carrier family 2, facilitated glucose transporter member 9

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6IJT3, D4A237
    Related
    ENSRNOP00000045713.2, ENSRNOT00000042200.3
    Conserved Domains (2) summary
    cd06174
    Location:49 → 486
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:47 → 502
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    76540649..76674277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273504.1 → XP_063129574.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X4

  2. XM_039092336.2 → XP_038948264.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW25, A0A8I6AVN8
    Related
    ENSRNOP00000097928.1
    Conserved Domains (1) summary
    cd17432
    Location:47 → 498
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  3. XM_006251100.4 → XP_006251162.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X2

    See identical proteins and their annotated locations for XP_006251162.1

    UniProtKB/TrEMBL
    A0A0G2JW25
    Conserved Domains (2) summary
    cd06174
    Location:27 → 464
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:25 → 480
    Sugar_tr; Sugar (and other) transporter

  4. XM_006251101.5 → XP_006251163.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X2

    See identical proteins and their annotated locations for XP_006251163.1

    UniProtKB/TrEMBL
    A0A0G2JW25
    Conserved Domains (2) summary
    cd06174
    Location:27 → 464
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:25 → 480
    Sugar_tr; Sugar (and other) transporter

  5. XM_063273505.1 → XP_063129575.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X5

  6. XM_006251102.5 → XP_006251164.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X3

    UniProtKB/TrEMBL
    A0A8I6G921, A6IJT3
    Related
    ENSRNOP00000083445.1
    Conserved Domains (2) summary
    cd06174
    Location:49 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:47 → 468
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein Strain
Heading Accession and Version

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