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OXTR oxytocin receptor [ Homo sapiens (human) ]

Gene ID: 5021, updated on 4-Jan-2025

Summary

Official Symbol
OXTRprovided by HGNC
Official Full Name
oxytocin receptorprovided by HGNC
Primary source
HGNC:HGNC:8529
See related
Ensembl:ENSG00000180914 MIM:167055; AllianceGenome:HGNC:8529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OTR; OT-R
Summary
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary (RPKM 1.0), endometrium (RPKM 1.0) and 16 other tissues See more
Orthologs
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Genomic context

See OXTR in Genome Data Viewer
Location:
3p25.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (8741269..8769613, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (8741551..8760789, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (8792067..8811299, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:8664536-8665156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19390 Neighboring gene ssu-2 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19393 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14028 Neighboring gene olfactory receptor family 7 subfamily E member 122 pseudogene Neighboring gene MPRA-validated peak4531 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr3:8765327-8765828 Neighboring gene caveolin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:8808751-8809422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14029 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:8810095-8810766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19394 Neighboring gene uncharacterized LOC107986061 Neighboring gene uncharacterized LOC107984112

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of comorbid depressive syndrome and alcohol dependence.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ionotropic glutamate receptor binding  
enables oxytocin receptor activity  
enables peptide hormone binding  
enables vasopressin receptor activity  
Items 1 - 25 of 37
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade  
involved_in G protein-coupled receptor signaling pathway  
involved_in cell surface receptor signaling pathway PubMed 
involved_in cellular response to hormone stimulus  
involved_in digestive tract development  
involved_in eating behavior  
involved_in estrous cycle  
involved_in female pregnancy  
involved_in heart development  
involved_in lactation PubMed 
involved_in maternal behavior  
involved_in maternal process involved in parturition  
involved_in memory  
involved_in muscle contraction PubMed 
involved_in positive regulation of blood pressure  
involved_in positive regulation of cold-induced thermogenesis PubMed 
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of norepinephrine secretion  
involved_in positive regulation of penile erection  
involved_in positive regulation of synapse assembly  
involved_in positive regulation of synaptic transmission, GABAergic  
involved_in positive regulation of synaptic transmission, glutamatergic  
involved_in positive regulation of uterine smooth muscle contraction  
involved_in positive regulation of vasoconstriction  
involved_in regulation of systemic arterial blood pressure by vasopressin  
involved_in response to amphetamine  
involved_in response to anoxia  
involved_in response to cocaine  
involved_in response to cytokine  
involved_in response to estradiol  
involved_in response to peptide hormone  
involved_in response to progesterone  
involved_in response to xenobiotic stimulus  
involved_in social behavior  
involved_in sperm ejaculation  
involved_in suckling behavior  
involved_in telencephalon development  
Items 1 - 25 of 37
Component Evidence Code Pubs
located_in adherens junction  
located_in apical plasma membrane  
located_in microvillus  
is_active_in plasma membrane  
located_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000916.4NP_000907.2  oxytocin receptor

    See identical proteins and their annotated locations for NP_000907.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 all encode the same protein.
    Source sequence(s)
    AC068312
    Consensus CDS
    CCDS2570.1
    UniProtKB/Swiss-Prot
    P30559, Q15071
    UniProtKB/TrEMBL
    B2R9L7
    Related
    ENSP00000324270.2, ENST00000316793.8
    Conserved Domains (1) summary
    cd15387
    Location:40340
    7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001354653.2NP_001341582.1  oxytocin receptor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same protein.
    Source sequence(s)
    AC068312
    Consensus CDS
    CCDS2570.1
    UniProtKB/Swiss-Prot
    P30559, Q15071
    UniProtKB/TrEMBL
    B2R9L7
    Conserved Domains (1) summary
    cd15387
    Location:40340
    7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001354654.2NP_001341583.1  oxytocin receptor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same protein.
    Source sequence(s)
    AC068312
    Consensus CDS
    CCDS2570.1
    UniProtKB/Swiss-Prot
    P30559, Q15071
    UniProtKB/TrEMBL
    B2R9L7
    Conserved Domains (1) summary
    cd15387
    Location:40340
    7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001354655.2NP_001341584.1  oxytocin receptor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same protein.
    Source sequence(s)
    AC068312
    Consensus CDS
    CCDS2570.1
    UniProtKB/Swiss-Prot
    P30559, Q15071
    UniProtKB/TrEMBL
    B2R9L7
    Conserved Domains (1) summary
    cd15387
    Location:40340
    7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_001354656.3NP_001341585.1  oxytocin receptor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same protein.
    Source sequence(s)
    AC068312
    Consensus CDS
    CCDS2570.1
    UniProtKB/Swiss-Prot
    P30559, Q15071
    UniProtKB/TrEMBL
    B2R9L7
    Conserved Domains (1) summary
    cd15387
    Location:40340
    7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    8741269..8769613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007095681.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    8741551..8760789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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