U.S. flag

An official website of the United States government

P2RX3 purinergic receptor P2X 3 [ Homo sapiens (human) ]

Gene ID: 5024, updated on 4-Jan-2025

Summary

Official Symbol
P2RX3provided by HGNC
Official Full Name
purinergic receptor P2X 3provided by HGNC
Primary source
HGNC:HGNC:8534
See related
Ensembl:ENSG00000109991 MIM:600843; AllianceGenome:HGNC:8534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2X3
Summary
This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]
Expression
Biased expression in testis (RPKM 1.0), heart (RPKM 0.8) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See P2RX3 in Genome Data Viewer
Location:
11q12.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57335950..57372396)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57285441..57321889)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57105826..57139869)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57067393-57068592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57070511-57071048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57071049-57071584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57071585-57072121 Neighboring gene tankyrase 1 binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3343 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4714 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57092719-57093592 Neighboring gene small nucleolar RNA U13 Neighboring gene structure specific recognition protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57117303-57117802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57132373-57132874 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57136946-57138145 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:57146812-57148011 Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 Neighboring gene proteoglycan 2, pro eosinophil major basic protein

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC129956

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in behavioral response to pain  
involved_in calcium ion transmembrane transport  
involved_in calcium ion transmembrane transport PubMed 
involved_in cellular response to ATP PubMed 
involved_in establishment of localization in cell  
involved_in excitatory postsynaptic potential  
involved_in inorganic cation transmembrane transport PubMed 
involved_in neuromuscular synaptic transmission  
involved_in peristalsis  
involved_in positive regulation of calcium ion transport into cytosol PubMed 
involved_in positive regulation of calcium-mediated signaling PubMed 
involved_in protein homotrimerization PubMed 
involved_in purinergic nucleotide receptor signaling pathway  
involved_in regulation of synaptic plasticity  
involved_in response to carbohydrate  
involved_in response to cold  
involved_in response to heat  
involved_in response to hypoxia  
involved_in response to mechanical stimulus  
involved_in sensory perception of taste  
involved_in signal transduction PubMed 
involved_in urinary bladder smooth muscle contraction  
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse  
located_in axon  
located_in hippocampal mossy fiber to CA3 synapse  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in postsynapse  
part_of receptor complex PubMed 

General protein information

Preferred Names
P2X purinoceptor 3
Names
ATP receptor
P2X receptor, subunit 3
purinergic receptor P2X, ligand gated ion channel, 3
purinergic receptor P2X3
purinoceptor P2X3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002559.5NP_002550.2  P2X purinoceptor 3

    See identical proteins and their annotated locations for NP_002550.2

    Status: REVIEWED

    Source sequence(s)
    AP000781, BC069162, BC074792, DB462670, HY032450
    Consensus CDS
    CCDS7953.1
    UniProtKB/Swiss-Prot
    P56373, Q6DK37, Q9UQB6
    Related
    ENSP00000263314.2, ENST00000263314.3
    Conserved Domains (1) summary
    pfam00864
    Location:8363
    P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    57335950..57372396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545070.3XP_011543372.1  P2X purinoceptor 3 isoform X1

    See identical proteins and their annotated locations for XP_011543372.1

    UniProtKB/Swiss-Prot
    P56373, Q6DK37, Q9UQB6
    Conserved Domains (1) summary
    pfam00864
    Location:8363
    P2X_receptor; ATP P2X receptor
  2. XM_011545069.3XP_011543371.1  P2X purinoceptor 3 isoform X1

    See identical proteins and their annotated locations for XP_011543371.1

    UniProtKB/Swiss-Prot
    P56373, Q6DK37, Q9UQB6
    Conserved Domains (1) summary
    pfam00864
    Location:8363
    P2X_receptor; ATP P2X receptor
  3. XM_011545072.3XP_011543374.1  P2X purinoceptor 3 isoform X3

    Conserved Domains (1) summary
    pfam00864
    Location:1289
    P2X_receptor; ATP P2X receptor
  4. XM_011545071.3XP_011543373.1  P2X purinoceptor 3 isoform X2

    Conserved Domains (1) summary
    pfam00864
    Location:8361
    P2X_receptor; ATP P2X receptor
  5. XM_011545073.2XP_011543375.1  P2X purinoceptor 3 isoform X4

    Conserved Domains (1) summary
    cl02993
    Location:1199
    P2X_receptor; ATP P2X receptor

RNA

  1. XR_949950.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    57285441..57321889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368990.1XP_054224965.1  P2X purinoceptor 3 isoform X5

  2. XM_054368989.1XP_054224964.1  P2X purinoceptor 3 isoform X5

  3. XM_054368992.1XP_054224967.1  P2X purinoceptor 3 isoform X7

  4. XM_054368988.1XP_054224963.1  P2X purinoceptor 3 isoform X5

  5. XM_054368991.1XP_054224966.1  P2X purinoceptor 3 isoform X6

  6. XM_054368993.1XP_054224968.1  P2X purinoceptor 3 isoform X8

External link. Please review our privacy policy.