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Srsf11 serine and arginine rich splicing factor 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 502603, updated on 13-Apr-2024

Summary

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Official Symbol
Srsf11provided by RGD
Official Full Name
serine and arginine rich splicing factor 11provided by RGD
Primary source
RGD:1559953
See related
Ensembl:ENSRNOG00000029592 AllianceGenome:RGD:1559953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sfrs11
Summary
Predicted to enable RNA binding activity and identical protein binding activity. Predicted to be involved in RNA splicing. Predicted to be located in nuclear speck. Predicted to be active in nucleoplasm. Orthologous to human SRSF11 (serine and arginine rich splicing factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 166.0), Spleen (RPKM 136.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Srsf11 in Genome Data Viewer
Location:
2q45
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (249733464..249760296, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (247074623..247101460, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (264837463..264864296, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 19 Neighboring gene cystathionine gamma-lyase Neighboring gene ankyrin repeat domain 13C Neighboring gene leucine rich repeat containing 40 Neighboring gene leucine rich repeat containing 7 Neighboring gene transfer RNA alanine (anticodon AGC) 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Discovering transcription and splicing networks in myelodysplastic syndromes. Wang H, et al. PLoS One, 2013. PMID 24244432, Free PMC Article
  2. Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders. Stamova BS, et al. Mol Autism, 2013 Sep 4. PMID 24007566, Free PMC Article
  3. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, et al. Nucleic Acids Res, 2007. PMID 17537823, Free PMC Article
  4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC116323

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/arginine-rich splicing factor 11
Names
splicing factor, arginine/serine-rich 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399822.1 → NP_001386751.1  serine/arginine-rich splicing factor 11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HWT5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    249733464..249760296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233542.5 → XP_006233604.1  serine/arginine-rich splicing factor 11 isoform X3

    UniProtKB/TrEMBL
    D3ZBT0, Q4KLK1
    Conserved Domains (1) summary
    cd12518
    Location:62 → 141
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  2. XM_008761567.4 → XP_008759789.1  serine/arginine-rich splicing factor 11 isoform X2

    UniProtKB/TrEMBL
    D3ZBT0, Q4KLK1
    Conserved Domains (1) summary
    cd12518
    Location:62 → 141
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  3. XM_006233540.5 → XP_006233602.1  serine/arginine-rich splicing factor 11 isoform X1

    UniProtKB/TrEMBL
    A0A0G2QC38, D3ZBT0, Q4KLK1
    Related
    ENSRNOP00000043202.6
    Conserved Domains (1) summary
    cd12518
    Location:62 → 141
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  4. XM_008761569.4 → XP_008759791.1  serine/arginine-rich splicing factor 11 isoform X5

    UniProtKB/TrEMBL
    D3ZBT0, Q4KLK1
    Conserved Domains (1) summary
    cd12518
    Location:27 → 106
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  5. XM_006233543.5 → XP_006233605.1  serine/arginine-rich splicing factor 11 isoform X4

    See identical proteins and their annotated locations for XP_006233605.1

    UniProtKB/TrEMBL
    D3ZBT0, Q4KLK1
    Conserved Domains (1) summary
    cd12518
    Location:41 → 120
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  6. XM_039102967.2 → XP_038958895.1  serine/arginine-rich splicing factor 11 isoform X7

    UniProtKB/TrEMBL
    A6HWT7

  7. XM_063282413.1 → XP_063138483.1  serine/arginine-rich splicing factor 11 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001035255.1: Suppressed sequence

    Description
    NM_001035255.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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