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Dok5 docking protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 502694, updated on 11-Apr-2024

Summary

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Symbol
Dok5provided by RGD
Full Name
docking protein 5provided by RGD
Primary source
RGD:1562846
See related
Ensembl:ENSRNOG00000013196 AllianceGenome:RGD:1562846
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562846
Summary
Predicted to enable kinase activity. Predicted to be involved in positive regulation of MAPK cascade and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within neuron differentiation and regulation of neurotrophin TRK receptor signaling pathway. Predicted to be active in cytoplasm. Orthologous to human DOK5 (docking protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 52.9), Brain (RPKM 48.3) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dok5 in Genome Data Viewer
Location:
3q42
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (179934419..180071334)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (159515886..159652811)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (168345116..168482445)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101807 Neighboring gene uncharacterized LOC120101808 Neighboring gene uncharacterized LOC120101806 Neighboring gene uncharacterized LOC134486495 Neighboring gene uncharacterized LOC102552784 Neighboring gene uncharacterized LOC108350532

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis. Pan Y, et al. Neurosci Lett, 2013 Oct 11. PMID 23954828
  2. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. Grimm J, et al. J Cell Biol, 2001 Jul 23. PMID 11470823, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
docking protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109344.2 → NP_001102814.1  docking protein 5

    See identical proteins and their annotated locations for NP_001102814.1

    Status: PROVISIONAL

    Source sequence(s)
    BC167027
    UniProtKB/TrEMBL
    A0A8I6A882, A0A9K3Y7G0, B2RZ51, F1LMM0
    Related
    ENSRNOP00000017654.6, ENSRNOT00000017654.8
    Conserved Domains (3) summary
    cd13164
    Location:133 → 235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9 → 113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
    pfam00169
    Location:8 → 111
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    179934419..180071334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235673.5 → XP_006235735.1  docking protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7S1, A0A8I6AWK3
    Related
    ENSRNOP00000097604.1
    Conserved Domains (3) summary
    cd13164
    Location:133 → 235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9 → 113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
    pfam00169
    Location:8 → 111
    PH; PH domain

  2. XM_063284407.1 → XP_063140477.1  docking protein 5 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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