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Lrrc17 leucine rich repeat containing 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 502715, updated on 5-Mar-2024

Summary

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Symbol
Lrrc17provided by RGD
Full Name
leucine rich repeat containing 17provided by RGD
Primary source
RGD:1560165
See related
Ensembl:ENSRNOG00000012817 AllianceGenome:RGD:1560165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in bone marrow development and negative regulation of osteoclast differentiation. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRRC17 (leucine rich repeat containing 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 61.7), Heart (RPKM 60.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrrc17 in Genome Data Viewer
Location:
4q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14393632..14424048, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13501428..13531845, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (10108184..10138652, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 10 Neighboring gene F-box and leucine-rich repeat protein 13 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORD86 Neighboring gene uncharacterized LOC134486551 Neighboring gene family with sequence similarity 185, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation. Kim T, et al. J Biol Chem, 2009 May 29. PMID 19336404, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in bone marrow development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025155.2 → NP_001020326.1  leucine-rich repeat-containing protein 17 precursor

    See identical proteins and their annotated locations for NP_001020326.1

    Status: VALIDATED

    Source sequence(s)
    BC079098, DY314273
    UniProtKB/TrEMBL
    F7ESW9, Q6AYD0
    Related
    ENSRNOP00000017103.3, ENSRNOT00000017103.5
    Conserved Domains (4) summary
    sd00033
    Location:68 → 86
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:299 → 337
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:273 → 333
    LRR_8; Leucine rich repeat
    cl15307
    Location:168 → 204
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    14393632..14424048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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