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Gria1 glutamate ionotropic receptor AMPA type subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50592, updated on 4-Jan-2025

Summary

Official Symbol
Gria1provided by RGD
Official Full Name
glutamate ionotropic receptor AMPA type subunit 1provided by RGD
Primary source
RGD:621531
See related
EnsemblRapid:ENSRNOG00000045816 AllianceGenome:RGD:621531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GluA1; gluR-A
Summary
Enables several functions, including enzyme binding activity; signaling receptor binding activity; and transmitter-gated monoatomic ion channel activity. Involved in several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; endosome membrane; and neuronal cell body membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Used to study cocaine dependence; hyperhomocysteinemia; morphine dependence; and withdrawal disorder. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; brain disease (multiple); cocaine abuse; and drug dependence (multiple). Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal recessive intellectual developmental disorder 76; and epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 421.7), Uterus (RPKM 41.0) and 1 other tissue See more
Orthologs
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Genomic context

See Gria1 in Genome Data Viewer
Location:
10q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (41710540..42030105)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (41210713..41527283)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (42441723..42760200)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095105 Neighboring gene uncharacterized LOC102553349 Neighboring gene uncharacterized LOC120095106 Neighboring gene family with sequence similarity 114, member A2 Neighboring gene microfibril associated protein 3 Neighboring gene uncharacterized LOC134480689 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 10

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 35
Function Evidence Code Pubs
enables AMPA glutamate receptor activity  
enables AMPA glutamate receptor activity PubMed 
enables AMPA glutamate receptor activity  
enables AMPA glutamate receptor activity  
enables G-protein alpha-subunit binding PubMed 
enables G-protein beta-subunit binding PubMed 
enables PDZ domain binding PubMed 
enables adenylate cyclase binding PubMed 
enables amyloid-beta binding PubMed 
enables beta-2 adrenergic receptor binding PubMed 
enables glutamate receptor binding PubMed 
enables glutamate-gated calcium ion channel activity PubMed 
enables glutamate-gated receptor activity PubMed 
enables glutamate-gated receptor activity  
enables identical protein binding PubMed 
enables immunoglobulin binding PubMed 
enables ionotropic glutamate receptor binding PubMed 
enables ligand-gated monoatomic ion channel activity  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables myosin V binding PubMed 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration  
enables peptide hormone receptor binding PubMed 
enables protein binding PubMed 
enables protein domain specific binding PubMed 
enables protein kinase A binding PubMed 
enables protein kinase binding PubMed 
enables scaffold protein binding PubMed 
enables signaling receptor activity  
enables small GTPase binding PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
Items 1 - 25 of 35
Items 1 - 25 of 64
Process Evidence Code Pubs
involved_in behavioral response to pain PubMed 
involved_in calcium-mediated signaling  
involved_in cellular response to L-glutamate PubMed 
involved_in cellular response to amine stimulus PubMed 
involved_in cellular response to amino acid stimulus PubMed 
involved_in cellular response to ammonium ion  
acts_upstream_of_or_within cellular response to ammonium ion  
involved_in cellular response to brain-derived neurotrophic factor stimulus PubMed 
involved_in cellular response to brain-derived neurotrophic factor stimulus PubMed 
involved_in cellular response to dsRNA PubMed 
involved_in cellular response to growth factor stimulus PubMed 
involved_in cellular response to organic cyclic compound PubMed 
involved_in cellular response to peptide hormone stimulus PubMed 
involved_in cerebral cortex development PubMed 
involved_in chemical synaptic transmission  
acts_upstream_of_or_within chemical synaptic transmission  
involved_in conditioned place preference PubMed 
involved_in ionotropic glutamate receptor signaling pathway  
involved_in long-term memory  
involved_in long-term memory PubMed 
involved_in long-term memory  
involved_in long-term synaptic depression  
acts_upstream_of_or_within long-term synaptic depression  
involved_in long-term synaptic potentiation PubMed 
involved_in modulation of chemical synaptic transmission  
involved_in modulation of chemical synaptic transmission PubMed 
involved_in monoatomic ion transmembrane transport  
involved_in neuronal action potential PubMed 
involved_in positive regulation of excitatory postsynaptic potential PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of locomotion involved in locomotory behavior PubMed 
involved_in positive regulation of membrane potential PubMed 
involved_in positive regulation of synaptic transmission PubMed 
involved_in receptor internalization PubMed 
involved_in receptor internalization  
involved_in receptor internalization  
involved_in regulation of monoatomic ion transmembrane transport PubMed 
involved_in regulation of postsynaptic cytosolic calcium ion concentration  
involved_in regulation of postsynaptic membrane potential  
involved_in regulation of presynaptic membrane potential  
involved_in regulation of receptor recycling PubMed 
involved_in regulation of synaptic plasticity PubMed 
involved_in regulation of synaptic plasticity PubMed 
involved_in response to arsenic-containing substance PubMed 
involved_in response to cocaine PubMed 
involved_in response to electrical stimulus PubMed 
involved_in response to estradiol PubMed 
involved_in response to ethanol PubMed 
involved_in response to fungicide PubMed 
involved_in response to lithium ion PubMed 
involved_in response to morphine PubMed 
involved_in response to morphine PubMed 
involved_in response to nutrient levels PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to peptide hormone PubMed 
involved_in response to psychosocial stress PubMed 
involved_in response to sucrose PubMed 
involved_in response to toxic substance PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in spinal cord development PubMed 
involved_in synapse assembly  
involved_in synapse assembly  
involved_in synaptic transmission, glutamatergic  
involved_in synaptic transmission, glutamatergic PubMed 
Items 1 - 25 of 64
Items 1 - 20 of 93
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex  
part_of AMPA glutamate receptor complex PubMed 
part_of AMPA glutamate receptor complex  
part_of AMPA glutamate receptor complex  
located_in asymmetric synapse PubMed 
located_in axonal spine  
located_in axonal spine  
located_in cell body  
located_in cell surface PubMed 
located_in cell surface  
is_active_in cell surface  
located_in cell surface  
located_in cell-cell junction PubMed 
located_in cytosol PubMed 
located_in dendrite PubMed 
located_in dendrite  
located_in dendrite  
located_in dendrite membrane PubMed 
located_in dendrite membrane  
located_in dendritic shaft PubMed 
is_active_in dendritic spine  
located_in dendritic spine PubMed 
located_in dendritic spine  
located_in dendritic spine membrane  
is_active_in dendritic spine membrane  
located_in dendritic spine membrane  
located_in early endosome PubMed 
located_in early endosome membrane PubMed 
located_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum membrane PubMed 
located_in excitatory synapse PubMed 
located_in excitatory synapse  
is_active_in excitatory synapse  
located_in external side of plasma membrane PubMed 
is_active_in glutamatergic synapse PubMed 
located_in glutamatergic synapse  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
located_in glutamatergic synapse  
part_of ionotropic glutamate receptor complex  
part_of ionotropic glutamate receptor complex PubMed 
located_in membrane  
located_in neuromuscular junction PubMed 
located_in neuron projection PubMed 
located_in neuron projection  
located_in neuron spine PubMed 
located_in neuron spine  
located_in neuronal cell body PubMed 
located_in neuronal cell body  
is_active_in neuronal cell body  
located_in neuronal cell body  
located_in neuronal cell body membrane PubMed 
located_in perisynaptic space  
located_in perisynaptic space  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in postsynapse  
located_in postsynaptic density PubMed 
located_in postsynaptic density  
is_active_in postsynaptic density membrane  
is_active_in postsynaptic density membrane PubMed 
located_in postsynaptic density membrane  
is_active_in postsynaptic density membrane  
located_in postsynaptic density membrane  
located_in postsynaptic density membrane  
located_in postsynaptic density, intracellular component PubMed 
is_active_in postsynaptic membrane PubMed 
located_in postsynaptic membrane  
located_in postsynaptic membrane  
located_in postsynaptic membrane  
located_in presynapse  
located_in presynapse  
is_active_in presynaptic active zone membrane PubMed 
is_active_in presynaptic membrane PubMed 
part_of protein-containing complex PubMed 
located_in proximal dendrite PubMed 
located_in recycling endosome  
located_in recycling endosome  
located_in recycling endosome membrane PubMed 
located_in somatodendritic compartment  
located_in synapse PubMed 
located_in synapse PubMed 
located_in synapse  
located_in synaptic membrane PubMed 
located_in synaptic membrane PubMed 
located_in synaptic membrane  
located_in synaptic vesicle  
located_in synaptic vesicle membrane  
located_in synaptic vesicle membrane  
Items 1 - 20 of 93

General protein information

Preferred Names
glutamate receptor 1
Names
AMPA-selective glutamate receptor 1
GluR1
gluR-1
gluR-K1
glutamate receptor A
glutamate receptor subunit GluR1
glutamate receptor, ionotropic, AMPA 1
glutamate receptor, ionotropic, AMPA1 (alpha 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031608.2NP_113796.1  glutamate receptor 1 precursor

    See identical proteins and their annotated locations for NP_113796.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P19490
    UniProtKB/TrEMBL
    A0A0G2K798, A6HEN8
    Related
    ENSRNOP00000101986.1, ENSRNOT00000144558.1
    Conserved Domains (2) summary
    cd13729
    Location:406787
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06390
    Location:26392
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    41710540..42030105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269677.1XP_063125747.1  glutamate receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K798, A6HEN9
    Related
    ENSRNOP00000074119.2, ENSRNOT00000081136.3
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