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Itih3 inter-alpha trypsin inhibitor, heavy chain 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50693, updated on 3-Apr-2024

Summary

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Official Symbol
Itih3provided by RGD
Official Full Name
inter-alpha trypsin inhibitor, heavy chain 3provided by RGD
Primary source
RGD:620633
See related
Ensembl:ENSRNOG00000017689 AllianceGenome:RGD:620633
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PAIHC3
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of endopeptidase activity. Predicted to be located in extracellular region. Orthologous to human ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 11567.5) See more
Orthologs
human mouse all
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Genomic context

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See Itih3 in Genome Data Viewer
Location:
16p16
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6108378..6123609, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6101922..6117154, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (6983779..7007288, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 4 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1 Neighboring gene NIMA-related kinase 4 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate. Kaczmarczyk A, et al. J Biol Chem, 2002 Apr 19. PMID 11827976
  2. [Interaction between hypertriglyceridemia and noise in human hearing]. Lahoz Zamarro MT, et al. Acta Otorrinolaringol Esp, 1992 Nov-Dec. PMID 1299283
  3. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate
    Title: Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
inter-alpha-trypsin inhibitor heavy chain H3
Names
ITI heavy chain H3
ITI-HC3
inter-alpha-inhibitor heavy chain 3
pre-alpha-inhibitor, heavy chain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017351.1 → NP_059047.1  inter-alpha-trypsin inhibitor heavy chain H3 precursor

    See identical proteins and their annotated locations for NP_059047.1

    Status: PROVISIONAL

    Source sequence(s)
    X83231
    UniProtKB/Swiss-Prot
    Q63416
    UniProtKB/TrEMBL
    A6KG20
    Related
    ENSRNOP00000023984.4, ENSRNOT00000023984.7
    Conserved Domains (4) summary
    smart00609
    Location:29 → 158
    VIT; Vault protein Inter-alpha-Trypsin domain
    TIGR03788
    Location:47 → 602
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam06668
    Location:681 → 868
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl00057
    Location:281 → 462
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    6108378..6123609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275657.1 → XP_063131727.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GKX5

  2. XM_063275656.1 → XP_063131726.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63416.1 GenPept UniProtKB/Swiss-Prot:Q63416

Gene LinkOut

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