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Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) [ Mus musculus (house mouse) ]

Gene ID: 50933, updated on 12-May-2024

Summary

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Official Symbol
Uchl3provided by MGI
Official Full Name
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)provided by MGI
Primary source
MGI:MGI:1355274
See related
Ensembl:ENSMUSG00000022111 AllianceGenome:MGI:1355274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UCH-L3
Summary
Enables deubiquitinase activity. Involved in cellular response to insulin stimulus; positive regulation of fat cell differentiation; and protein catabolic process. Acts upstream of or within several processes, including adult walking behavior; eating behavior; and protein deubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including embryo ectoderm; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 31.8), testis adult (RPKM 30.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Uchl3 in Genome Data Viewer
Location:
14 E2.3; 14 50.9 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (101891387..101933561)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (101653892..101696125)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 4 Neighboring gene predicted gene, 34417 Neighboring gene STARR-seq mESC enhancer starr_37476 Neighboring gene STARR-positive B cell enhancer ABC_E7344 Neighboring gene STARR-positive B cell enhancer ABC_E8574 Neighboring gene COMM domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_37480 Neighboring gene STARR-positive B cell enhancer ABC_E2432 Neighboring gene STARR-seq mESC enhancer starr_37481 Neighboring gene STARR-positive B cell enhancer ABC_E11786 Neighboring gene HCLS1 associated X-1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37482 Neighboring gene predicted gene 9922

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses. Setsuie R, et al. Neurochem Int, 2010 Jul. PMID 20380862
  2. Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle. Setsuie R, et al. FASEB J, 2009 Dec. PMID 19671667
  3. Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice. Sano Y, et al. Am J Pathol, 2006 Jul. PMID 16816367, Free PMC Article
  4. Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory. Wood MA, et al. Hippocampus, 2005. PMID 15884048
  5. Expression and functional analysis of Uch-L3 during mouse development. Kurihara LJ, et al. Mol Cell Biol, 2000 Apr. PMID 10713173, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
    Title: Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
  2. The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
    Title: The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
  3. Data suggest that the activity of oocyte UCHL-1 and -3 contributes to oocyte maturation by regulating the oocyte cortex and meiotic spindle.
    Title: Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation.
  4. subfertile Uchl1(gad-/-) mutant mice showed an intriguing pattern of switched UCH localization, with UCHL3 replacing UCHL1 in the oocyte cortex
    Title: Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development.
  5. impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie
    Title: Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
  6. Results suggest that Uch-L3 enhances osteoblast differentiation through the stabilization of Smad1 signaling
    Title: Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation.
  7. Polyubiquitinated proteins accumulate in skeletal muscle as well as in mouse embryonic fibroblasts derived from Uchl3-deficient mice.
    Title: Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses.
  8. Results suggest that UCH-L3 promotes adipogenesis by enhancing insulin signaling in a hydrolase activity-dependent manner.
    Title: Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis.
  9. The role of ubiquitin C-terminal hydrolase (UCH)-L3 in the regulation of AMP-activated protein kinase activity and whole-body energy metabolism are reportedl
    Title: Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.
  10. Data show that Uchl3 and mitofilin are differentially expressed in the hippocampi of inbred senescence-acclerated mice compared to normally-aging mice.
    Title: The hippocampal proteomic analysis of senescence-accelerated mouse: implications of Uchl3 and mitofilin in cognitive disorder and mitochondria dysfunction in SAMP8.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult walking behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within eating behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein deubiquitination ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L3
Names
ubiquitin thioesterase L3
ubiquitin thiolesterase
NP_057932.2
XP_006519309.1
XP_006519310.3
XP_006519311.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428941.1 → NP_001415870.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT025630

  2. NM_001428942.1 → NP_001415871.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT025630

  3. NM_001428943.1 → NP_001415872.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT025630

  4. NM_001428944.1 → NP_001415873.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT025630

  5. NM_016723.3 → NP_057932.2  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 3

    See identical proteins and their annotated locations for NP_057932.2

    Status: VALIDATED

    Source sequence(s)
    CT025630
    Consensus CDS
    CCDS27313.1
    UniProtKB/Swiss-Prot
    Q9EQX7, Q9JKB1
    Related
    ENSMUSP00000002289.6, ENSMUST00000002289.8
    Conserved Domains (1) summary
    cd09616
    Location:6 → 227
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    101891387..101933561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519246.5 → XP_006519309.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X1

    Conserved Domains (1) summary
    cd09616
    Location:39 → 365
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  2. XM_006519248.4 → XP_006519311.3  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X3

    Conserved Domains (1) summary
    cd09616
    Location:39 → 301
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  3. XM_006519247.4 → XP_006519310.3  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X2

    UniProtKB/TrEMBL
    A0A2I3BQ39
    Related
    ENSMUSP00000154032.2, ENSMUST00000226340.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKB1.2 GenPept UniProtKB/Swiss-Prot:Q9JKB1

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