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IBD5 inflammatory bowel disease 5 [ Homo sapiens (human) ]

Gene ID: 50941, updated on 22-Aug-2020

Summary

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Gene symbol
IBD5
Gene description
inflammatory bowel disease 5
Primary source
MIM:606348
Gene type
unknown
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Genomic context

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Location:
5q31-q33

Bibliography

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Related articles in PubMed

  1. Contribution of the IBD5 locus to inflammatory bowel disease: a meta-analysis. Wang J, et al. Hum Genet, 2011 Jun. PMID 21279723
  2. IBD5 is associated with an extensive complicated Crohn's disease feature: implications from genotype-phenotype analysis. Brescianini S, et al. Gut, 2007 Jan. PMID 17172589, Free PMC Article
  3. Role of the IBD5 susceptibility locus in the inflammatory bowel diseases. Reinhard C, et al. Inflamm Bowel Dis, 2006 Mar. PMID 16534425
  4. IBD5 polymorphisms in inflammatory bowel disease: association with response to infliximab. Urcelay E, et al. World J Gastroenterol, 2005 Feb 28. PMID 15754402, Free PMC Article
  5. Association between inflammatory bowel disease gene 5 (IBD5) and interleukin-23 receptor (IL23R) genetic polymorphisms in Malaysian patients with Crohn's disease. Chua KH, et al. J Dig Dis, 2012 Sep. PMID 22908971

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There is a strong association between both IBD5 locus variants but not the IL23R gene variant with Crohn disease in the Malaysian population.
    Title: Association between inflammatory bowel disease gene 5 (IBD5) and interleukin-23 receptor (IL23R) genetic polymorphisms in Malaysian patients with Crohn's disease.
  2. results suggested that the IBD5 locus contributes to the susceptibility of CD in a per-allele manner in adults, children and Caucasians, and the locus contributes to the susceptibility of UC in a recessive manner in adult and Caucasian populations
    Title: Contribution of the IBD5 locus to inflammatory bowel disease: a meta-analysis.
  3. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.
  4. All IBD5 SNPs tested were in linkage disequilibrium (D'>0.8), and showed significant association with Crohn disease in our cohort of Ashkenazi Jewish children.
    Title: Polymorphisms in the IBD5 locus are associated with Crohn disease in pediatric Ashkenazi Jewish patients.
  5. ATG16L1, IBD5, and IL23R SNPs were significantly associated with Crohn's Disease
    Title: Contributions of IBD5, IL23R, ATG16L1, and NOD2 to Crohn's disease risk in a population-based case-control study: evidence of gene-gene interactions.
  6. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: IBD5 is associated with an extensive complicated Crohn's disease feature: implications from genotype-phenotype analysis.
  7. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.
  9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: IBD5 polymorphisms in inflammatory bowel disease: association with response to infliximab.
  10. IL23R is a susceptibility gene for inflammatory bowel disease with suggestive epistasis with the IBD5 locus in the Crohn's disease population
    Title: Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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EBI GWAS Catalog

Description
Inflammatory bowel disease 5
EBI GWAS Catalog

General gene information

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Markers

Property

  • phenotype only

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