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PCM1 pericentriolar material 1 [ Homo sapiens (human) ]

Gene ID: 5108, updated on 4-Jan-2025

Summary

Official Symbol
PCM1provided by HGNC
Official Full Name
pericentriolar material 1provided by HGNC
Primary source
HGNC:HGNC:8727
See related
Ensembl:ENSG00000078674 MIM:600299; AllianceGenome:HGNC:8727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTC4; RET/PCM-1
Summary
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Broad expression in testis (RPKM 47.5), thyroid (RPKM 18.5) and 25 other tissues See more
Orthologs
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Genomic context

See PCM1 in Genome Data Viewer
Location:
8p22
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (17922988..18029948)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (18190478..18297432)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17780497..17887457)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene fibrinogen like 1 Neighboring gene endogenous retrovirus group K member 25 Env polyprotein-like Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:17769002-17769792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:17769793-17770581 Neighboring gene Sharpr-MPRA regulatory region 2266 Neighboring gene uncharacterized LOC124901867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27048 Neighboring gene Sharpr-MPRA regulatory region 9839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27050 Neighboring gene uncharacterized LOC124901894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:17911125-17911698 Neighboring gene N-acylsphingosine amidohydrolase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18966 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:17942063-17942598 Neighboring gene ASAH1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding  
enables molecular adaptor activity PubMed 
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in centrosome cycle PubMed 
involved_in cilium assembly PubMed 
acts_upstream_of_or_within cytoplasmic microtubule organization PubMed 
involved_in cytoplasmic microtubule organization PubMed 
involved_in interkinetic nuclear migration  
involved_in intraciliary transport involved in cilium assembly PubMed 
involved_in microtubule anchoring  
involved_in microtubule anchoring at centrosome  
involved_in negative regulation of neurogenesis  
involved_in neuron migration  
involved_in neuronal stem cell population maintenance  
involved_in non-motile cilium assembly  
involved_in non-motile cilium assembly PubMed 
involved_in positive regulation of intracellular protein transport PubMed 
involved_in protein localization to centrosome  
acts_upstream_of_or_within protein localization to centrosome PubMed 
involved_in protein localization to centrosome  
involved_in protein-containing complex localization to centriolar satellite PubMed 
involved_in regulation of protein complex stability PubMed 
involved_in social behavior  
Component Evidence Code Pubs
located_in apical part of cell  
is_active_in centriolar satellite  
is_active_in centriolar satellite PubMed 
located_in centriolar satellite PubMed 
located_in centriole  
colocalizes_with centrosome PubMed 
located_in centrosome PubMed 
located_in centrosome  
is_active_in ciliary basal body  
located_in ciliary transition zone PubMed 
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in membrane PubMed 
NOT located_in non-motile cilium PubMed 
located_in nuclear membrane  
located_in nucleoplasm  
located_in pericentriolar material  
part_of protein-containing complex PubMed 

General protein information

Preferred Names
pericentriolar material 1 protein
Names
PCM-1
hPCM-1
pericentriolar material 1, PCM1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027690.2 RefSeqGene

    Range
    5002..111962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001315507.2NP_001302436.2  pericentriolar material 1 protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS83256.1
    UniProtKB/TrEMBL
    A0A5H1ZRS1, B9EIS5
    Related
    ENSP00000431099.1, ENST00000519253.5
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13721990
    PCM1_C; Pericentriolar material 1 C-terminus
  2. NM_001315508.2NP_001302437.2  pericentriolar material 1 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame segments compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS83255.1
    UniProtKB/TrEMBL
    A0A4W8VX11, A2RUU9
    Related
    ENSP00000430521.1, ENST00000524226.5
    Conserved Domains (1) summary
    pfam15717
    Location:13181834
    PCM1_C; Pericentriolar material 1 C-terminus
  3. NM_001352632.2NP_001339561.2  pericentriolar material 1 protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    COG1196
    Location:226463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:14112041
    PCM1_C; Pericentriolar material 1 C-terminus
  4. NM_001352633.2NP_001339562.2  pericentriolar material 1 protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    COG1196
    Location:226463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:14182036
    PCM1_C; Pericentriolar material 1 C-terminus
  5. NM_001352634.2NP_001339563.2  pericentriolar material 1 protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13722002
    PCM1_C; Pericentriolar material 1 C-terminus
  6. NM_001352635.2NP_001339564.2  pericentriolar material 1 protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13731991
    PCM1_C; Pericentriolar material 1 C-terminus
  7. NM_001352636.2NP_001339565.2  pericentriolar material 1 protein isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    COG1196
    Location:226463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:13571983
    PCM1_C; Pericentriolar material 1 C-terminus
  8. NM_001352637.2NP_001339566.2  pericentriolar material 1 protein isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    COG1196
    Location:226463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:13561982
    PCM1_C; Pericentriolar material 1 C-terminus
  9. NM_001352638.2NP_001339567.2  pericentriolar material 1 protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    COG1196
    Location:226463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:13561974
    PCM1_C; Pericentriolar material 1 C-terminus
  10. NM_001352639.2NP_001339568.2  pericentriolar material 1 protein isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13171947
    PCM1_C; Pericentriolar material 1 C-terminus
  11. NM_001352640.2NP_001339569.2  pericentriolar material 1 protein isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13181944
    PCM1_C; Pericentriolar material 1 C-terminus
  12. NM_001352641.2NP_001339570.2  pericentriolar material 1 protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13171939
    PCM1_C; Pericentriolar material 1 C-terminus
  13. NM_001352642.2NP_001339571.2  pericentriolar material 1 protein isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    A2RUU9
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13171833
    PCM1_C; Pericentriolar material 1 C-terminus
  14. NM_001352643.2NP_001339572.2  pericentriolar material 1 protein isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    COG1196
    Location:226463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:14111509
    PCM1_C; Pericentriolar material 1 C-terminus
  15. NM_001352644.2NP_001339573.2  pericentriolar material 1 protein isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform 16.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13171943
    PCM1_C; Pericentriolar material 1 C-terminus
  16. NM_001352645.2NP_001339574.2  pericentriolar material 1 protein isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform 16.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13171943
    PCM1_C; Pericentriolar material 1 C-terminus
  17. NM_001352646.2NP_001339575.2  pericentriolar material 1 protein isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 19, encodes isoform 17.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13171935
    PCM1_C; Pericentriolar material 1 C-terminus
  18. NM_001352647.2NP_001339576.2  pericentriolar material 1 protein isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variant 18, encodes isoform 17.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13171935
    PCM1_C; Pericentriolar material 1 C-terminus
  19. NM_001352648.2NP_001339577.2  pericentriolar material 1 protein isoform 18

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variant 21, encodes isoform 18.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13181936
    PCM1_C; Pericentriolar material 1 C-terminus
  20. NM_001352649.2NP_001339578.2  pericentriolar material 1 protein isoform 18

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variant 20, encodes isoform 18.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13181936
    PCM1_C; Pericentriolar material 1 C-terminus
  21. NM_001352650.2NP_001339579.2  pericentriolar material 1 protein isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variant 23, encodes isoform 19.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    COG1196
    Location:226463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:14112037
    PCM1_C; Pericentriolar material 1 C-terminus
  22. NM_001352651.2NP_001339580.2  pericentriolar material 1 protein isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variant 22, encodes isoform 19.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    COG1196
    Location:226463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:14112037
    PCM1_C; Pericentriolar material 1 C-terminus
  23. NM_001352652.2NP_001339581.2  pericentriolar material 1 protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 24, and 25 encode isoform 1.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS47812.1
    UniProtKB/Swiss-Prot
    A6NNN6, B4DYD5, E7ETA6, E7EV56, Q15154, Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13721998
    PCM1_C; Pericentriolar material 1 C-terminus
  24. NM_001352653.2NP_001339582.2  pericentriolar material 1 protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 24, and 25 encode isoform 1.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS47812.1
    UniProtKB/Swiss-Prot
    A6NNN6, B4DYD5, E7ETA6, E7EV56, Q15154, Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13721998
    PCM1_C; Pericentriolar material 1 C-terminus
  25. NM_001352654.2NP_001339583.2  pericentriolar material 1 protein isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 27 and 28, encodes isoform 21.
    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    TIGR02302
    Location:231447
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13171415
    PCM1_C; Pericentriolar material 1 C-terminus
  26. NM_001352655.2NP_001339584.2  pericentriolar material 1 protein isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 26 and 28, encodes isoform 21.
    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    TIGR02302
    Location:231447
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13171415
    PCM1_C; Pericentriolar material 1 C-terminus
  27. NM_001352656.2NP_001339585.2  pericentriolar material 1 protein isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 26 and 27, encodes isoform 21.
    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    TIGR02302
    Location:231447
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13171415
    PCM1_C; Pericentriolar material 1 C-terminus
  28. NM_001352657.2NP_001339586.2  pericentriolar material 1 protein isoform 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variant 30, encodes isoform 22.
    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13721470
    PCM1_C; Pericentriolar material 1 C-terminus
  29. NM_001352658.2NP_001339587.2  pericentriolar material 1 protein isoform 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variant 29, encodes isoform 22.
    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13721470
    PCM1_C; Pericentriolar material 1 C-terminus
  30. NM_001352659.2NP_001339588.2  pericentriolar material 1 protein isoform 23

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variant 32, encodes isoform 23.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS87582.1
    UniProtKB/TrEMBL
    E9PGW9
    Related
    ENSP00000428123.1, ENST00000518537.5
    Conserved Domains (1) summary
    COG1196
    Location:226463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  31. NM_001352660.2NP_001339589.2  pericentriolar material 1 protein isoform 23

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variant 31, encodes isoform 23.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS87582.1
    UniProtKB/TrEMBL
    E9PGW9
    Conserved Domains (1) summary
    COG1196
    Location:226463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  32. NM_006197.4NP_006188.4  pericentriolar material 1 protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 24, and 25 encode isoform 1.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS47812.1
    UniProtKB/Swiss-Prot
    A6NNN6, B4DYD5, E7ETA6, E7EV56, Q15154, Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2
    UniProtKB/TrEMBL
    H0YBA1
    Related
    ENSP00000327077.8, ENST00000325083.13
    Conserved Domains (2) summary
    TIGR02302
    Location:231450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:13721998
    PCM1_C; Pericentriolar material 1 C-terminus

RNA

  1. NR_148032.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    17922988..18029948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    18190478..18297432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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