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PDYN prodynorphin [ Homo sapiens (human) ]

Gene ID: 5173, updated on 4-Jan-2025

Summary

Official Symbol
PDYNprovided by HGNC
Official Full Name
prodynorphinprovided by HGNC
Primary source
HGNC:HGNC:8820
See related
Ensembl:ENSG00000101327 MIM:131340; AllianceGenome:HGNC:8820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADCA; PENKB; SCA23
Summary
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Restricted expression toward brain (RPKM 14.6) See more
Orthologs
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Genomic context

See PDYN in Genome Data Viewer
Location:
20p13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (1978756..1994285, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (2008889..2024418, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1959402..1974931, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17460 Neighboring gene uncharacterized LOC124904857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1856587-1857086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1859821-1860322 Neighboring gene uncharacterized LOC102724545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1871108-1871632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1876698-1877213 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:1880839-1881408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1882505-1883004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12597 Neighboring gene signal regulatory protein alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1917714-1918268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1918269-1918821 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1920335-1920836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1920837-1921336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1926175-1926721 Neighboring gene Sharpr-MPRA regulatory region 9993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1928155-1928702 Neighboring gene Sharpr-MPRA regulatory region 1230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17462 Neighboring gene PDYN antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr20:1945208-1945758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1974244-1975074 Neighboring gene Sharpr-MPRA regulatory region 7514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2075323-2075824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2075825-2076324 Neighboring gene ribosomal protein L7 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12600 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2083234-2084202 Neighboring gene uncharacterized LOC124900458 Neighboring gene serine/threonine kinase 35

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

EBI GWAS Catalog

Description
Genome-wide association study of antibody response to smallpox vaccine.
EBI GWAS Catalog
Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.
EBI GWAS Catalog
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC26418

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables opioid peptide activity  
enables opioid receptor binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission  
involved_in neuropeptide signaling pathway  
involved_in sensory perception  
Component Evidence Code Pubs
is_active_in axon terminus  
is_active_in dendrite  
located_in extracellular region  
is_active_in hippocampal mossy fiber to CA3 synapse PubMed 
is_active_in neuronal cell body  
is_active_in neuronal dense core vesicle PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 

General protein information

Preferred Names
proenkephalin-B
Names
beta-neoendorphin-dynorphin
leu-enkephalin
leumorphin
neoendorphin-dynorphin-enkephalin prepropeptide
preprodynorphin
preproenkephalin B
rimorphin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028027.1 RefSeqGene

    Range
    5188..20487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_667

mRNA and Protein(s)

  1. NM_001190892.1NP_001177821.1  proenkephalin-B preproprotein

    See identical proteins and their annotated locations for NP_001177821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR sequence and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AK289618, AL034562, BC026334
    Consensus CDS
    CCDS13023.1
    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  2. NM_001190898.3NP_001177827.1  proenkephalin-B preproprotein

    See identical proteins and their annotated locations for NP_001177827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, which results in three nt less than variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AL034562, BC026334, DA297229
    Consensus CDS
    CCDS13023.1
    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  3. NM_001190899.2NP_001177828.1  proenkephalin-B preproprotein

    See identical proteins and their annotated locations for NP_001177828.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AL034562, BC026334, DA157767, DA178888, DA302375
    Consensus CDS
    CCDS13023.1
    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Related
    ENSP00000440185.1, ENST00000539905.5
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  4. NM_001190900.1NP_001177829.1  proenkephalin-B preproprotein

    See identical proteins and their annotated locations for NP_001177829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' UTR exon, as compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AL034562, BC026334, DA305883
    Consensus CDS
    CCDS13023.1
    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Related
    ENSP00000442259.1, ENST00000540134.5
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  5. NM_024411.5NP_077722.1  proenkephalin-B preproprotein

    See identical proteins and their annotated locations for NP_077722.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2-5 encode the same protein.
    Source sequence(s)
    AL034562, BC026334, DA178888
    Consensus CDS
    CCDS13023.1
    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Related
    ENSP00000217305.2, ENST00000217305.3
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    1978756..1994285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529249.3XP_011527551.1  proenkephalin-B isoform X1

    See identical proteins and their annotated locations for XP_011527551.1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  2. XM_011529247.1XP_011527549.1  proenkephalin-B isoform X1

    See identical proteins and their annotated locations for XP_011527549.1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  3. XM_017027878.1XP_016883367.1  proenkephalin-B isoform X1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  4. XM_011529248.2XP_011527550.1  proenkephalin-B isoform X1

    See identical proteins and their annotated locations for XP_011527550.1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  5. XM_011529246.3XP_011527548.1  proenkephalin-B isoform X1

    See identical proteins and their annotated locations for XP_011527548.1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  6. XM_011529244.2XP_011527546.1  proenkephalin-B isoform X1

    See identical proteins and their annotated locations for XP_011527546.1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  7. XM_011529245.1XP_011527547.1  proenkephalin-B isoform X1

    See identical proteins and their annotated locations for XP_011527547.1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  8. XM_011529250.3XP_011527552.1  proenkephalin-B isoform X1

    See identical proteins and their annotated locations for XP_011527552.1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
    Conserved Domains (1) summary
    pfam01160
    Location:2167
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    2008889..2024418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323505.1XP_054179480.1  proenkephalin-B isoform X1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
  2. XM_054323503.1XP_054179478.1  proenkephalin-B isoform X1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
  3. XM_054323504.1XP_054179479.1  proenkephalin-B isoform X1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
  4. XM_054323501.1XP_054179476.1  proenkephalin-B isoform X1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
  5. XM_054323500.1XP_054179475.1  proenkephalin-B isoform X1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
  6. XM_054323499.1XP_054179474.1  proenkephalin-B isoform X1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
  7. XM_054323502.1XP_054179477.1  proenkephalin-B isoform X1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
  8. XM_054323506.1XP_054179481.1  proenkephalin-B isoform X1

    UniProtKB/Swiss-Prot
    A8K0Q3, P01213
    UniProtKB/TrEMBL
    Q2YEL0
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