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SERPINB9 serpin family B member 9 [ Homo sapiens (human) ]

Gene ID: 5272, updated on 4-Jan-2025

Summary

Official Symbol
SERPINB9provided by HGNC
Official Full Name
serpin family B member 9provided by HGNC
Primary source
HGNC:HGNC:8955
See related
Ensembl:ENSG00000170542 MIM:601799; AllianceGenome:HGNC:8955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI9; CAP3; PI-9; CAP-3
Summary
This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]
Expression
Broad expression in placenta (RPKM 26.1), appendix (RPKM 19.1) and 21 other tissues See more
Orthologs
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Genomic context

See SERPINB9 in Genome Data Viewer
Location:
6p25.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (2887270..2903309, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (2753393..2769547, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (2887504..2903543, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 71 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23875 Neighboring gene serpin family B member 9 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23877 Neighboring gene microRNA 4645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:2869952-2870526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:2875298-2876239 Neighboring gene SERPINB9 antisense RNA 1 Neighboring gene MPRA-validated peak5624 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:2903007-2903508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16837 Neighboring gene hESC enhancers GRCh37_chr6:2907997-2908830 and GRCh37_chr6:2908831-2909664 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:2916616-2917158 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:2921833-2922334 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:2928364-2929022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:2929023-2929682 Neighboring gene serpin family B member 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:2960063-2960678 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:2971582-2972106 Neighboring gene SERPINB6-LINC01011 intergenic CAGE-defined mid-level expression enhancer Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:2988143-2988952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:2988953-2989762 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:2989763-2990572 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:2990573-2991380 Neighboring gene long intergenic non-protein coding RNA 1011 Neighboring gene NQO2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi apparatus  
located_in collagen-containing extracellular matrix PubMed 
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol PubMed 
located_in extracellular exosome PubMed 
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in membrane PubMed 
located_in nucleoplasm  
located_in nucleus PubMed 

General protein information

Preferred Names
serpin B9
Names
cytoplasmic antiproteinase 3
peptidase inhibitor 9
protease inhibitor 9 (ovalbumin type)
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
serpin peptidase inhibitor, clade B (ovalbumin), member 9
serpin peptidase inhibitor, clade B, member 9
testicular tissue protein Li 180

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004155.6NP_004146.1  serpin B9

    See identical proteins and their annotated locations for NP_004146.1

    Status: REVIEWED

    Source sequence(s)
    AL133351, BC002538, BX485378
    Consensus CDS
    CCDS4478.1
    UniProtKB/Swiss-Prot
    B2RBW3, P50453, Q5TD03
    UniProtKB/TrEMBL
    A0A024QZT4
    Related
    ENSP00000370074.4, ENST00000380698.5
    Conserved Domains (1) summary
    cl00137
    Location:4376
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    2887270..2903309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249184.6XP_005249241.1  serpin B9 isoform X1

    See identical proteins and their annotated locations for XP_005249241.1

    UniProtKB/Swiss-Prot
    B2RBW3, P50453, Q5TD03
    UniProtKB/TrEMBL
    A0A024QZT4
    Conserved Domains (1) summary
    cl00137
    Location:4376
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  2. XM_011514678.3XP_011512980.1  serpin B9 isoform X2

    See identical proteins and their annotated locations for XP_011512980.1

    Conserved Domains (1) summary
    cl00137
    Location:13325
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  3. XM_047418894.1XP_047274850.1  serpin B9 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    2753393..2769547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355640.1XP_054211615.1  serpin B9 isoform X1

    UniProtKB/Swiss-Prot
    B2RBW3, P50453, Q5TD03
    UniProtKB/TrEMBL
    A0A024QZT4
  2. XM_054355641.1XP_054211616.1  serpin B9 isoform X2

  3. XM_054355642.1XP_054211617.1  serpin B9 isoform X2

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