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Lair1 leukocyte-associated Ig-like receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 52855, updated on 12-May-2024

Summary

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Official Symbol
Lair1provided by MGI
Official Full Name
leukocyte-associated Ig-like receptor 1provided by MGI
Primary source
MGI:MGI:105492
See related
Ensembl:ENSMUSG00000055541 AllianceGenome:MGI:105492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lair-1; D7Bwg0421e; 5133400O11Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including LAIR1 (leukocyte associated immunoglobulin like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 2.8), frontal lobe adult (RPKM 1.2) and 25 other tissues See more
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Genomic context

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Location:
7 A1; 7 2.31 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4010072..4076566, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4007073..4073567, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7363 Neighboring gene STARR-seq mESC enhancer starr_17916 Neighboring gene predicted gene 15928 Neighboring gene STARR-seq mESC enhancer starr_17917 Neighboring gene RIKEN cDNA 9430041J12 gene Neighboring gene predicted gene, 23741 Neighboring gene STARR-seq mESC enhancer starr_17919 Neighboring gene RIKEN cDNA D030047H15 gene Neighboring gene tweety family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. 1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis. Myers LK, et al. Int J Mol Sci, 2021 Dec 12. PMID 34948139, Free PMC Article
  2. LAIR-1 Limits Neutrophilic Airway Inflammation. Kumawat K, et al. Front Immunol, 2019. PMID 31080449, Free PMC Article
  3. Leukocyte-Associated Ig-like Receptor 1 Inhibits T(h)1 Responses but Is Required for Natural and Induced Monocyte-Dependent T(h)17 Responses. Agashe VV, et al. J Immunol, 2018 Jul 15. PMID 29884698, Free PMC Article
  4. The Role of Leukocyte-Associated Ig-like Receptor-1 in Suppressing Collagen-Induced Arthritis. Kim S, et al. J Immunol, 2017 Oct 15. PMID 28887430, Free PMC Article
  5. Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets. Smith CW, et al. Arterioscler Thromb Vasc Biol, 2017 May. PMID 28336561

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression.
    Title: Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression.
  2. 1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis.
    Title: 1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis.
  3. Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway.
    Title: Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway.
  4. collagen degradation fragments inhibit osteoclast formation acting through LAIR-1, providing a novel mechanism for the physiologically-relevant negative control of osteoclastogenesis
    Title: Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation.
  5. absence of LAIR-1 in myocardial infarct mice does not influence infarct size, inflammation, fibrosis or adverse cardiac remodelling.
    Title: Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice.
  6. this study shows that LAIR1 inhibits Th1 Responses but Is required for natural and induced monocyte-dependent Th17 responses
    Title: Leukocyte-Associated Ig-like Receptor 1 Inhibits T(h)1 Responses but Is Required for Natural and Induced Monocyte-Dependent T(h)17 Responses.
  7. these data demonstrate that collagen can suppress the T cell cytokine response through the action of LAIR-1, and that LAIR-1-/- mice develop more severe arthritis
    Title: The Role of Leukocyte-Associated Ig-like Receptor-1 in Suppressing Collagen-Induced Arthritis.
  8. LAIR-1 in megakaryocytes leads to increased Src family kinase activity and downstream signaling in response to collagen that is transmitted to platelets, rendering them hyper-reactive specifically to agonists that signal through Syk tyrosine kinases.
    Title: Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.
  9. The LAIR1-SHP-1-CAMK1-CREB pathway sustains the survival and self-renewal of AML stem cells.
    Title: The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development.
  10. LAIR-1-deficient mice are healthy and fertile with normal longevity, showing increased numbers of splenic B, regulatory T, and dendritic cells.
    Title: Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leukocyte-associated immunoglobulin-like receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113474.1 → NP_001106945.1  leukocyte-associated immunoglobulin-like receptor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001106945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) encodes the longest isoform (a).
    Source sequence(s)
    AK033472, AK044465, AK050281, BY284244, BY515495
    Consensus CDS
    CCDS51969.1
    UniProtKB/Swiss-Prot
    Q80UN5, Q8BG84, Q8BHB6, Q8BRR6, Q8C6N8, Q8CEP5
    UniProtKB/TrEMBL
    G8JL64
    Related
    ENSMUSP00000083589.4, ENSMUST00000086401.10
    Conserved Domains (1) summary
    cl11960
    Location:27 → 118
    Ig; Immunoglobulin domain

  2. NM_001302675.1 → NP_001289604.1  leukocyte-associated immunoglobulin-like receptor 1 isoform e precursor

    See identical proteins and their annotated locations for NP_001289604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) lacks an in-frame exon in the coding region compared to variant a. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC161037, AK033472, AY392766, BY284244, BY515495
    Consensus CDS
    CCDS80654.1
    UniProtKB/TrEMBL
    G8JL64
    Related
    ENSMUSP00000104241.3, ENSMUST00000108600.9
    Conserved Domains (1) summary
    cl11960
    Location:27 → 118
    Ig; Immunoglobulin domain

  3. NM_001302676.1 → NP_001289605.1  leukocyte-associated immunoglobulin-like receptor 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) lacks two in-frame exons in the coding region compared to variant a. It encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AC161037, AK033472, BY204263, BY284244, BY515495
    UniProtKB/Swiss-Prot
    Q8BG84

  4. NM_001302677.1 → NP_001289606.1  leukocyte-associated immunoglobulin-like receptor 1 isoform d precursor

    See identical proteins and their annotated locations for NP_001289606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) lacks two in-frame exons in the coding region compared to variant a. It encodes isoform d, which is shorter than isoform a.
    Source sequence(s)
    AC161037, AK033472, AY392765, BY284244, BY515495
    Consensus CDS
    CCDS85202.1
    UniProtKB/Swiss-Prot
    Q8BG84
    Related
    ENSMUSP00000145940.2, ENSMUST00000205296.2

  5. NM_001302681.1 → NP_001289610.1  leukocyte-associated immunoglobulin-like receptor 1 isoform f

    See identical proteins and their annotated locations for NP_001289610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (f) differs in the 5' UTR, uses an alternate splice site at an internal exon, and initiates translation at an alternate start codon compared to variant a. The encoded isoform (f) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC161037, AK033472, AK054158, AY392763, BY284244, BY515495
    UniProtKB/TrEMBL
    G8JL64
    Conserved Domains (1) summary
    cl11960
    Location:22 → 113
    Ig; Immunoglobulin domain

  6. NM_001302682.1 → NP_001289611.1  leukocyte-associated immunoglobulin-like receptor 1 isoform g

    See identical proteins and their annotated locations for NP_001289611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (g) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple coding region differences, one of which results in a frameshift in the 3' coding region compared to variant a. The encoded isoform (g) has a distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC161037, AK033472, AK054158, BY284244, BY515495
    UniProtKB/Swiss-Prot
    Q8BG84
    Conserved Domains (1) summary
    cl11960
    Location:22 → 113
    Ig; Immunoglobulin domain

  7. NM_001302683.1 → NP_001289612.1  leukocyte-associated immunoglobulin-like receptor 1 isoform h

    See identical proteins and their annotated locations for NP_001289612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (h) differs in the 5'UTR, has multiple coding region differences, and initiates translation at an alternate start codon compared to variant a. The encoded isoform (h) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC161037, AK033472, AK043664, BY284244, BY515495
    UniProtKB/Swiss-Prot
    Q8BG84

  8. NM_178611.6 → NP_848726.1  leukocyte-associated immunoglobulin-like receptor 1 isoform b

    See identical proteins and their annotated locations for NP_848726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) lacks an in-frame exon in the coding region compared to variant a. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AK033472, AK050281, BY284244, BY515495
    Consensus CDS
    CCDS20729.1
    UniProtKB/Swiss-Prot
    Q8BG84
    Related
    ENSMUSP00000070712.6, ENSMUST00000068865.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4010072..4076566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540179.5 → XP_006540242.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X2

    See identical proteins and their annotated locations for XP_006540242.1

    UniProtKB/TrEMBL
    G8JL64
    Conserved Domains (1) summary
    cl11960
    Location:22 → 113
    Ig; Immunoglobulin domain

  2. XM_006540176.4 → XP_006540239.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006540239.1

    UniProtKB/Swiss-Prot
    Q80UN5, Q8BG84, Q8BHB6, Q8BRR6, Q8C6N8, Q8CEP5
    UniProtKB/TrEMBL
    G8JL64
    Conserved Domains (1) summary
    cl11960
    Location:27 → 118
    Ig; Immunoglobulin domain

  3. XM_006540175.4 → XP_006540238.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006540238.1

    UniProtKB/Swiss-Prot
    Q80UN5, Q8BG84, Q8BHB6, Q8BRR6, Q8C6N8, Q8CEP5
    UniProtKB/TrEMBL
    G8JL64
    Conserved Domains (1) summary
    cl11960
    Location:27 → 118
    Ig; Immunoglobulin domain

  4. XM_036153240.1 → XP_036009133.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X3

    UniProtKB/TrEMBL
    G8JL64
    Conserved Domains (2) summary
    cd00096
    Location:18 → 21
    Ig; Ig strand A [structural motif]
    cl11960
    Location:18 → 106
    Ig; Immunoglobulin domain

  5. XM_006540183.5 → XP_006540246.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG84.1 GenPept UniProtKB/Swiss-Prot:Q8BG84

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