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PKD3 polycystic kidney disease 3 (autosomal dominant) [ Homo sapiens (human) ]

Gene ID: 5312, updated on 20-Feb-2022

Summary

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Gene symbol
PKD3
Gene description
polycystic kidney disease 3 (autosomal dominant)
Primary source
MIM:600666
Gene type
unknown
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Genomic context

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Location:
2p

Bibliography

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Related articles in PubMed

  1. Protein Kinase D3 Promotes the Reconstruction of OSCC Immune Escape Niche Via Regulating MHC-I and Immune Inhibit Molecules Expression. Lv D, et al. J Immunother, 2021 Nov-Dec 01. PMID 34545012
  2. PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling. Cui B, et al. Int J Oral Sci, 2021 Mar 10. PMID 33692335, Free PMC Article
  3. Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes. Baker J, et al. PLoS One, 2018. PMID 29652915, Free PMC Article
  4. Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101. Borges S, et al. Mol Cancer Ther, 2015 Jun. PMID 25852060, Free PMC Article
  5. Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2. Chen J, et al. Cancer Res, 2008 May 15. PMID 18483269

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein Kinase D3 Promotes the Reconstruction of OSCC Immune Escape Niche Via Regulating MHC-I and Immune Inhibit Molecules Expression.
    Title: Protein Kinase D3 Promotes the Reconstruction of OSCC Immune Escape Niche Via Regulating MHC-I and Immune Inhibit Molecules Expression.
  2. PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling.
    Title: PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling.
  3. Our data indicate that PKD3 functions downstream of PKCiota to affect the cytokine-mediated induction of MMP1 and MMP13 in human chondrocytes.
    Title: Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes.
  4. Data show that similar to a knockdown of serine/threonine kinase protein kinase D3 (PKD3), treatment with this inhibitor targets all tumorigenic processes in vitro and decreases growth of primary tumors and metastasis in vivo
    Title: Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101.
  5. these data suggest that PKD2 and PKD3 coordinate to promote prostate cancer cell invasion through p65 NF-kappaB- and HDAC1-mediated expression and activation of uPA.
    Title: PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-κB- and HDAC1-mediated expression and activation of uPA.
  6. reveal a novel distinction between the exocrine and endocrine cells of the pancreas and further identify PKD3 as a signaling molecule that promotes hormone-stimulated amylase secretion
    Title: PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion.
  7. PKD3 contributes to growth and survival of prostate cancer cells
    Title: Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2.
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Phenotypes

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polycystic kidney disease 3 (autosomal dominant)

General gene information

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Property

  • phenotype only

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