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PLA2G1B phospholipase A2 group IB [ Homo sapiens (human) ]

Gene ID: 5319, updated on 4-Jan-2025

Summary

Official Symbol
PLA2G1Bprovided by HGNC
Official Full Name
phospholipase A2 group IBprovided by HGNC
Primary source
HGNC:HGNC:9030
See related
Ensembl:ENSG00000170890 MIM:172410; AllianceGenome:HGNC:9030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLA2; PLA2A; PPLA2
Summary
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Expression
Restricted expression toward pancreas (RPKM 9662.9) See more
Orthologs
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Genomic context

See PLA2G1B in Genome Data Viewer
Location:
12q24.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120322115..120327779, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120309295..120314955, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120759918..120765582, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120730693-120731684 Neighboring gene sirtuin 4 Neighboring gene RNA, U4 small nuclear 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120752165-120752348 Neighboring gene RNA, U6 small nuclear 1088, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120753363-120754138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7141 Neighboring gene musashi RNA binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120794238-120794738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120796175-120796787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120796788-120797399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120798696-120799414 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120799415-120800132 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120803530-120803720 Neighboring gene ribosomal protein S27 pseudogene 25

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC119834, MGC119835

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bile acid binding PubMed 
enables calcium ion binding  
enables calcium ion binding PubMed 
enables calcium-dependent phospholipase A2 activity  
enables calcium-dependent phospholipase A2 activity PubMed 
enables calcium-independent phospholipase A2 activity  
enables phospholipase A2 activity PubMed 
enables phospholipid binding  
enables signaling receptor binding  
enables signaling receptor binding PubMed 
enables signaling receptor binding PubMed 
Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in actin filament organization PubMed 
involved_in activation of phospholipase A2 activity PubMed 
involved_in antibacterial humoral response PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide PubMed 
involved_in arachidonate secretion PubMed 
involved_in cellular response to insulin stimulus PubMed 
involved_in defense response to Gram-positive bacterium PubMed 
involved_in fatty acid biosynthetic process PubMed 
involved_in innate immune response in mucosa PubMed 
involved_in intracellular signal transduction PubMed 
involved_in leukotriene biosynthetic process PubMed 
involved_in lipid catabolic process PubMed 
involved_in neutrophil chemotaxis PubMed 
involved_in neutrophil mediated immunity PubMed 
involved_in phosphatidylcholine metabolic process  
involved_in phosphatidylcholine metabolic process PubMed 
involved_in phosphatidylglycerol metabolic process  
involved_in phosphatidylglycerol metabolic process PubMed 
acts_upstream_of positive regulation of MAP kinase activity PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity PubMed 
involved_in positive regulation of calcium ion transport into cytosol PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of fibroblast proliferation PubMed 
involved_in positive regulation of immune response PubMed 
acts_upstream_of positive regulation of interleukin-8 production PubMed 
involved_in positive regulation of podocyte apoptotic process PubMed 
involved_in positive regulation of protein secretion PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in regulation of D-glucose import PubMed 
involved_in signal transduction PubMed 
Items 1 - 25 of 30
Component Evidence Code Pubs
located_in cell surface PubMed 
located_in extracellular region  
located_in extracellular space PubMed 

General protein information

Preferred Names
phospholipase A2
Names
phosphatidylcholine 2-acylhydrolase 1B
phospholipase A2, group IB (pancreas)
NP_000919.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000928.3NP_000919.1  phospholipase A2 precursor

    See identical proteins and their annotated locations for NP_000919.1

    Status: VALIDATED

    Source sequence(s)
    AA844927, M21054
    Consensus CDS
    CCDS9195.1
    UniProtKB/Swiss-Prot
    B2R4H5, P04054, Q3KPI1
    UniProtKB/TrEMBL
    F8W062
    Related
    ENSP00000312286.4, ENST00000308366.9
    Conserved Domains (1) summary
    smart00085
    Location:24146
    PA2c; Phospholipase A2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    120322115..120327779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    120309295..120314955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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