Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells |
PubMed
|
|
env
|
Lck is recuited to a virological synapse (VS) interface and is highly colocalized with gp120 when cells interact with gp120+ICAM-1 bilayers, leading to activate ZAP70, LAT, SLP76, and PLCgamma |
PubMed
|
Envelope surface glycoprotein gp160, precursor
|
env
|
Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells |
PubMed
|
|
env
|
HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity |
PubMed
|
Nef
|
nef
|
The early phosphorylation of PLC-gamma1 is impaired by HIV-1 Nef in sub-optimally activated/resting T cells |
PubMed
|
Pr55(Gag)
|
gag
|
SPRY2 interactions with PI(4,5)P2 and PLCgamma allow it to influence HIV-1 Gag release through interference with PI(4,5)P2 dynamics |
PubMed
|
|
gag
|
Phospholipase C-gamma is required for HIV-1 Gag release in the presence or absence of TSG101 binding |
PubMed
|
Tat
|
tat
|
Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat |
PubMed
|
|
tat
|
HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C |
PubMed
|
Go to the HIV-1, Human Interaction Database