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B4galt2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 53418, updated on 12-May-2024

Summary

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Official Symbol
B4galt2provided by MGI
Official Full Name
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2provided by MGI
Primary source
MGI:MGI:1858493
See related
Ensembl:ENSMUSG00000028541 AllianceGenome:MGI:1858493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ggtb2; b4Gal-T2; beta4Gal-T2
Summary
Predicted to enable galactosyltransferase activity. Acts upstream of or within cerebellar Purkinje cell layer development; learning or memory; and locomotory behavior. Predicted to be located in nucleoplasm. Predicted to be active in Golgi apparatus. Is expressed in early conceptus; eye; gonad; and nervous system. Orthologous to human B4GALT2 (beta-1,4-galactosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 21.0), ovary adult (RPKM 20.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 53.7 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117730211..117740724, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117873000..117883519, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 4_1138.1 Neighboring gene solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Neighboring gene coiled-coil domain containing 24 Neighboring gene predicted gene, 40233 Neighboring gene predicted gene 12841 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit B Neighboring gene STARR-positive B cell enhancer ABC_E4652 Neighboring gene DPH2 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient mice. Yoshihara T, et al. J Biol Chem, 2009 May 1. PMID 19265195, Free PMC Article
  2. Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development. Nakamura N, et al. J Neurochem, 2001 Jan. PMID 11145975
  3. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Lo NW, et al. Glycobiology, 1998 May. PMID 9597550
  4. Identification of novel oocyte and granulosa cell markers. Malcuit C, et al. Gene Expr Patterns, 2009 Sep. PMID 19539053
  5. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyllactosamine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lactose synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell layer development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 2
Names
N-acetyllactosamine synthase
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2
beta-1,4-GalTase 2
beta-1,4-galactosyltransferase II
beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
lactose synthase A protein
nal synthase
NP_001240310.1
NP_001413067.1
NP_059073.1
XP_011238877.1
XP_036020131.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253381.2 → NP_001240310.1  beta-1,4-galactosyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_001240310.1

    Status: VALIDATED

    Source sequence(s)
    AL627128
    Consensus CDS
    CCDS18539.1
    UniProtKB/Swiss-Prot
    Q3TMP2, Q9Z2Y2
    UniProtKB/TrEMBL
    B1ASJ2
    Related
    ENSMUSP00000102029.3, ENSMUST00000106421.9
    Conserved Domains (1) summary
    cd00899
    Location:142 → 358
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  2. NM_001426138.1 → NP_001413067.1  beta-1,4-galactosyltransferase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627128

  3. NM_017377.6 → NP_059073.1  beta-1,4-galactosyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_059073.1

    Status: VALIDATED

    Source sequence(s)
    AL627128
    Consensus CDS
    CCDS18539.1
    UniProtKB/Swiss-Prot
    Q3TMP2, Q9Z2Y2
    UniProtKB/TrEMBL
    B1ASJ2
    Related
    ENSMUSP00000030266.6, ENSMUST00000030266.12
    Conserved Domains (1) summary
    cd00899
    Location:142 → 358
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RNA

  1. NR_045570.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627128
    Related
    ENSMUST00000167443.8

  2. NR_189666.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627128

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117730211..117740724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164238.1 → XP_036020131.1  beta-1,4-galactosyltransferase 2 isoform X2

    Conserved Domains (1) summary
    cd00899
    Location:142 → 320
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  2. XM_011240575.4 → XP_011238877.1  beta-1,4-galactosyltransferase 2 isoform X1

    Conserved Domains (1) summary
    cl11394
    Location:142 → 317
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RNA

  1. XR_867887.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2Y2.1 GenPept UniProtKB/Swiss-Prot:Q9Z2Y2

Gene LinkOut

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