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PLXNA2 plexin A2 [ Homo sapiens (human) ]

Gene ID: 5362, updated on 4-Jan-2025

Summary

Official Symbol
PLXNA2provided by HGNC
Official Full Name
plexin A2provided by HGNC
Primary source
HGNC:HGNC:9100
See related
Ensembl:ENSG00000076356 MIM:601054; AllianceGenome:HGNC:9100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCT; PLXN2
Summary
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 8.4), lung (RPKM 6.9) and 23 other tissues See more
Orthologs
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Genomic context

See PLXNA2 in Genome Data Viewer
Location:
1q32.2
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (208022242..208244384, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (207268990..207491104, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (208195587..208417729, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985253 Neighboring gene NANOG hESC enhancer GRCh37_chr1:208091350-208091981 Neighboring gene CD34 molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208131807-208132308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208132309-208132808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208137516-208138045 Neighboring gene long intergenic non-protein coding RNA 2767 Neighboring gene uncharacterized LOC105372887 Neighboring gene uncharacterized LOC124904499 Neighboring gene uncharacterized LOC124904500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208332738-208333250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208333251-208333761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208347975-208348475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208352531-208353087 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:208353211-208354164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208371351-208371856 Neighboring gene Sharpr-MPRA regulatory region 4965 Neighboring gene uncharacterized LOC105372884 Neighboring gene Sharpr-MPRA regulatory region 12529 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:208416267-208416768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:208416769-208417268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1777 Neighboring gene uncharacterized LOC105372889 Neighboring gene uncharacterized LOC124904501 Neighboring gene NANOG hESC enhancer GRCh37_chr1:208443936-208444517 Neighboring gene MPRA-validated peak670 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:208547462-208548227 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:208551780-208552116 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:208586461-208586653 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1772 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1780 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1801 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:208618537-208619736 Neighboring gene uncharacterized LOC107985460

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ11751, FLJ30634, KIAA0463

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding  
enables protein binding PubMed 
enables semaphorin receptor activity  
enables semaphorin receptor activity  
Process Evidence Code Pubs
involved_in centrosome localization  
involved_in cerebellar granule cell precursor tangential migration  
involved_in limb bud formation  
involved_in neural tube development  
involved_in pharyngeal system development  
involved_in regulation of cell migration  
involved_in regulation of cell migration  
involved_in semaphorin-plexin signaling pathway  
involved_in semaphorin-plexin signaling pathway  
involved_in somitogenesis  
involved_in synapse assembly  
Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
part_of semaphorin receptor complex  
part_of semaphorin receptor complex PubMed 

General protein information

Preferred Names
plexin-A2
Names
plexin 2
semaphorin receptor OCT
transmembrane protein OCT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025179.4NP_079455.3  plexin-A2 precursor

    See identical proteins and their annotated locations for NP_079455.3

    Status: REVIEWED

    Source sequence(s)
    AB007932, AL356275, AL544219, AL606753, DA500239, H11743, X87831
    Consensus CDS
    CCDS31013.1
    UniProtKB/Swiss-Prot
    A2RTX9, B2RMX7, O75051, Q6UX61, Q96GN9, Q9BRL1, Q9UIW1
    Related
    ENSP00000356000.3, ENST00000367033.4
    Conserved Domains (7) summary
    cd11272
    Location:38552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd01179
    Location:9541037
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:858953
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10411141
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:806855
    PSI; Plexin repeat
    pfam01833
    Location:11431227
    TIG; IPT/TIG domain
    pfam08337
    Location:13111864
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    208022242..208244384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273164.4XP_005273221.1  plexin-A2 isoform X1

    Conserved Domains (7) summary
    cd11272
    Location:53567
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd01179
    Location:9691052
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:873968
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10561156
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:821870
    PSI; Plexin repeat
    pfam01833
    Location:11581242
    TIG; IPT/TIG domain
    pfam08337
    Location:13261944
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
  2. XM_005273165.5XP_005273222.1  plexin-A2 isoform X2

    Conserved Domains (7) summary
    cd11272
    Location:53567
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd01179
    Location:9691052
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:873968
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10561156
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:821870
    PSI; Plexin repeat
    pfam01833
    Location:11581242
    TIG; IPT/TIG domain
    pfam08337
    Location:13261823
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    207268990..207491104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337094.1XP_054193069.1  plexin-A2 isoform X1

  2. XM_054337095.1XP_054193070.1  plexin-A2 isoform X2

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