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B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 53625, updated on 9-May-2024

Summary

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Official Symbol
B3gnt2provided by MGI
Official Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2provided by MGI
Primary source
MGI:MGI:1889505
See related
Ensembl:ENSMUSG00000051650 AllianceGenome:MGI:1889505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BGnT1; BGnT2; B3gnt1; BGnT-1; BGnT-2; B3Galt6; Beta3gnt
Summary
Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and sensory perception of smell. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and nose. Orthologous to human B3GNT2 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 23.2), colon adult (RPKM 14.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A3.2; 11 14.22 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (22784739..22810336, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (22834739..22860336, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8389 Neighboring gene methionine aminopeptidase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28885 Neighboring gene STARR-positive B cell enhancer ABC_E6962 Neighboring gene ribosomal protein S16 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:22715949-22716150 Neighboring gene STARR-seq mESC enhancer starr_28889 Neighboring gene STARR-seq mESC enhancer starr_28890 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:22753904-22754057 Neighboring gene predicted gene, 24917 Neighboring gene STARR-seq mESC enhancer starr_28892 Neighboring gene COMM domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3935 Neighboring gene STARR-seq mESC enhancer starr_28894 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance. Knott TK, et al. Neural Dev, 2012 Jul 4. PMID 22559903, Free PMC Article
  2. Beta3GnT2 (B3GNT2), a major polylactosamine synthase: analysis of B3GNT2-deficient mice. Togayachi A, et al. Methods Enzymol, 2010. PMID 20816167
  3. Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation. Togayachi A, et al. Proc Natl Acad Sci U S A, 2007 Oct 2. PMID 17890318, Free PMC Article
  4. Molecular cloning and expression analysis of a mouse UDP-GlcNAc:Gal(beta1-4)Glc(NAc)-R beta1,3-N-acetylglucosaminyltransferase homologous to Drosophila melanogaster Brainiac and the beta1,3-galactosyltransferase family. Egan S, et al. Glycoconj J, 2000 Dec. PMID 11511811
  5. Lactosamine modulates the rate of migration of GnRH neurons during mouse development. Bless E, et al. Eur J Neurosci, 2006 Aug. PMID 16930397

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data clearly suggest that GCNT2 functions in vivo together with beta3GnT2 to determine poly-N-acetyllactosamine (PLN) levels in olfactory neurons by regulating beta1,6-branches that promote PLN extension.
    Title: N-linked polylactosamine glycan synthesis is regulated by co-expression of β3GnT2 and GCNT2.
  2. These results identify a novel function for beta3GnT2 glycosylation in maintaining expression of layer-specific vomeronasal receptors
    Title: β3GnT2 null mice exhibit defective accessory olfactory bulb innervation.
  3. Beta3GnT2(-/-) mice exhibit a relatively small deficit in their ability to discriminate divergent odors.
    Title: Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance.
  4. The results suggested taht beta3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium.
    Title: β3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium.
  5. In beta1,3-N-acetylglucosaminyltransferase (B3gnt2) B3gnt2-deficient (B3gnt2-/-) mice, the number of polylactosamine structures was markedly lower than in wild-type mice
    Title: Beta3GnT2 (B3GNT2), a major polylactosamine synthase: analysis of B3GNT2-deficient mice.
  6. up-regulation of beta3Gn-T8 in differentiated cells increases poly-N-acetyllactosamine chains by activating intrinsic beta3Gn-T2.
    Title: Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in poly-N-acetyllactosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly-N-acetyllactosamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
Names
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
beta-1,3-Gn-T1
beta-1,3-Gn-T2
beta-1,3-N-acetylglucosaminyltransferase 1
beta-1,3-N-acetylglucosaminyltransferase 2
beta3Gn-T1
beta3Gn-T2
NP_001162585.1
NP_058584.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169114.1 → NP_001162585.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

    See identical proteins and their annotated locations for NP_001162585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different exon for its 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL772364
    Consensus CDS
    CCDS24471.1
    UniProtKB/Swiss-Prot
    Q91V18, Q9Z222
    UniProtKB/TrEMBL
    Q3TVJ9
    Related
    ENSMUSP00000053528.4, ENSMUST00000055549.4
    Conserved Domains (1) summary
    cl21608
    Location:156 → 345
    Galactosyl_T; Galactosyltransferase

  2. NM_016888.5 → NP_058584.3  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

    See identical proteins and their annotated locations for NP_058584.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL772364
    Consensus CDS
    CCDS24471.1
    UniProtKB/Swiss-Prot
    Q91V18, Q9Z222
    UniProtKB/TrEMBL
    Q3TVJ9
    Related
    ENSMUSP00000060247.11, ENSMUST00000062844.11
    Conserved Domains (1) summary
    cl21608
    Location:156 → 345
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    22784739..22810336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z222.3 GenPept UniProtKB/Swiss-Prot:Q9Z222

Gene LinkOut

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