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PMCH pro-melanin concentrating hormone [ Homo sapiens (human) ]

Gene ID: 5367, updated on 4-Jan-2025

Summary

Official Symbol
PMCHprovided by HGNC
Official Full Name
pro-melanin concentrating hormoneprovided by HGNC
Primary source
HGNC:HGNC:9109
See related
Ensembl:ENSG00000183395 MIM:176795; AllianceGenome:HGNC:9109
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCH; ppMCH
Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015]
Expression
Broad expression in bone marrow (RPKM 1.1), lymph node (RPKM 0.9) and 21 other tissues See more
Orthologs
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Genomic context

See PMCH in Genome Data Viewer
Location:
12q23.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (102196459..102197833, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (102157595..102158969, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (102590237..102591611, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6878 Neighboring gene nucleoporin 37 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6879 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:102514807-102515364 Neighboring gene PARP1 binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:102546739-102547240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6880 Neighboring gene uncharacterized LOC124902998 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_22888 Neighboring gene RNA, 7SL, cytoplasmic 793, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Identification of 15 loci influencing height in a Korean population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation  
involved_in chemical synaptic transmission  
involved_in feeding behavior  
involved_in negative regulation of synaptic transmission, dopaminergic  
involved_in neuropeptide signaling pathway  
involved_in spermatogenesis  
Component Evidence Code Pubs
located_in extracellular region PubMed 
located_in extracellular region  
located_in nucleus  
located_in synapse  

General protein information

Preferred Names
pro-MCH
Names
prepro-MCH
prepro-melanin-concentrating hormone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002674.4NP_002665.2  pro-MCH preproprotein

    See identical proteins and their annotated locations for NP_002665.2

    Status: REVIEWED

    Source sequence(s)
    CB047052, CB047053
    Consensus CDS
    CCDS31885.1
    UniProtKB/Swiss-Prot
    P20382, Q16044, Q8WVG0
    Related
    ENSP00000332225.4, ENST00000329406.5
    Conserved Domains (1) summary
    pfam05824
    Location:84165
    Pro-MCH; Pro-melanin-concentrating hormone (Pro-MCH)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    102196459..102197833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019483.3XP_016874972.1  pro-MCH isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    102157595..102158969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372307.1XP_054228282.1  pro-MCH isoform X1

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