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Prrc2a proline-rich coiled-coil 2A [ Mus musculus (house mouse) ]

Gene ID: 53761, updated on 5-Mar-2024

Summary

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Official Symbol
Prrc2aprovided by MGI
Official Full Name
proline-rich coiled-coil 2Aprovided by MGI
Primary source
MGI:MGI:1915467
See related
Ensembl:ENSMUSG00000024393 AllianceGenome:MGI:1915467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G2; Bat2; Bat-2; Wbp12; D17H6S51E; mKIAA4178; 3110039B05Rik
Summary
Predicted to be involved in cell differentiation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PRRC2A (proline rich coiled-coil 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 97.6), adrenal adult (RPKM 89.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 18.59 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35368052..35384877, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35149076..35165321, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5599 Neighboring gene apolipoprotein M Neighboring gene BCL2-associated athanogene 6 Neighboring gene STARR-positive B cell enhancer ABC_E3201 Neighboring gene STARR-positive B cell enhancer ABC_E2486 Neighboring gene predicted gene, 23442 Neighboring gene STARR-positive B cell enhancer ABC_E5600 Neighboring gene allograft inflammatory factor 1 Neighboring gene natural cytotoxicity triggering receptor 3, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination. Wu R, et al. Cell Res, 2019 Jan. PMID 30514900, Free PMC Article
  2. Fine mapping of the crossover-sites in the C4-H-2D region of H-2 recombinant mouse strains. Snoek M, et al. Immunogenetics, 1991. PMID 1684177
  3. Identification of a recombinational breakpoint at the BAT5 locus in three intra-H-2 recombinant inbred mouse strains. Mathew PA, et al. Exp Clin Immunogenet, 1995. PMID 8919359
  4. RFLP analysis of the MHC class III region defines unique haplotypes for the non-obese diabetic, cataract Shionogi and the non-obese non-diabetic mouse strains. Lund T, et al. Diabetologia, 1993 Aug. PMID 8104833
  5. Localization of the casein kinase II beta-subunit gene within the mouse H-2 complex class III region and comparison of expression with Bat genes. Lanning D, et al. Mamm Genome, 1997 Jul. PMID 9196000

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4178

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein PRRC2A
Names
HLA-B associated transcript 2
large proline-rich protein BAT2
proline-rich and coiled-coil-containing protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199044.1 → NP_001185973.1  protein PRRC2A isoform 2

    See identical proteins and their annotated locations for NP_001185973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice acceptor site in the 3' coding region, compared to variant 1, which results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    BC052630, BC053522, CJ107441
    UniProtKB/TrEMBL
    G3UX48
    Related
    ENSMUSP00000133550.2, ENSMUST00000174805.2
    Conserved Domains (2) summary
    PHA03247
    Location:1475 → 1899
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 187
    BAT2_N; BAT2 N-terminus

  2. NM_020027.3 → NP_064411.2  protein PRRC2A isoform 1

    See identical proteins and their annotated locations for NP_064411.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC053522, CJ107441
    Consensus CDS
    CCDS37596.1
    UniProtKB/Swiss-Prot
    Q7TSC1, Q923A9, Q9Z1R1
    UniProtKB/TrEMBL
    G3UX48
    Related
    ENSMUSP00000025253.6, ENSMUST00000025253.12
    Conserved Domains (2) summary
    PHA03247
    Location:1475 → 1900
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 186
    BAT2_N; BAT2 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35368052..35384877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249899.2 → XP_030105759.1  protein PRRC2A isoform X2

    UniProtKB/TrEMBL
    G3UX48
    Conserved Domains (2) summary
    PHA03247
    Location:1475 → 1899
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 187
    BAT2_N; BAT2 N-terminus

  2. XM_006524620.5 → XP_006524683.1  protein PRRC2A isoform X1

    See identical proteins and their annotated locations for XP_006524683.1

    UniProtKB/Swiss-Prot
    Q7TSC1, Q923A9, Q9Z1R1
    UniProtKB/TrEMBL
    G3UX48
    Conserved Domains (2) summary
    PHA03247
    Location:1475 → 1900
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 186
    BAT2_N; BAT2 N-terminus

  3. XM_030249900.1 → XP_030105760.1  protein PRRC2A isoform X3

    UniProtKB/TrEMBL
    G3UX48
    Conserved Domains (2) summary
    PHA03247
    Location:1465 → 1890
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 177
    BAT2_N; BAT2 N-terminus

  4. XM_006524621.5 → XP_006524684.1  protein PRRC2A isoform X3

    See identical proteins and their annotated locations for XP_006524684.1

    UniProtKB/TrEMBL
    G3UX48
    Conserved Domains (2) summary
    PHA03247
    Location:1465 → 1890
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 177
    BAT2_N; BAT2 N-terminus

RNA

  1. XR_004939552.1 RNA Sequence

  2. XR_004939551.1 RNA Sequence

  3. XR_004939553.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSC1.1 GenPept UniProtKB/Swiss-Prot:Q7TSC1

Gene LinkOut

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