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PPP1R12A protein phosphatase 1 regulatory subunit 12A [ Bos taurus (cattle) ]

Gene ID: 538606, updated on 3-Apr-2024

Summary

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Official Symbol
PPP1R12Aprovided by VGNC
Official Full Name
protein phosphatase 1 regulatory subunit 12Aprovided by VGNC
Primary source
VGNC:VGNC:33223
See related
BGD:BT29208; Ensembl:ENSBTAG00000014609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (9309307..9477670, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin 1 Neighboring gene uncharacterized LOC104972334 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene pro-apoptotic WT1 regulator Neighboring gene otogelin like Neighboring gene uncharacterized LOC132345238 Neighboring gene protein tyrosine phosphatase receptor type Q

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC148828

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of myosin-light-chain-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in A band IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 12A
Names
protein phosphatase 1, regulatory (inhibitor) subunit 12A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102217.1 → NP_001095687.1  protein phosphatase 1 regulatory subunit 12A

    See identical proteins and their annotated locations for NP_001095687.1

    Status: PROVISIONAL

    Source sequence(s)
    BC149332
    UniProtKB/TrEMBL
    A6QPI0, F1N3L1
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199 → 252
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    9309307..9477670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024991984.2 → XP_024847752.1  protein phosphatase 1 regulatory subunit 12A isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MLL6
    Related
    ENSBTAP00000062810.2, ENSBTAT00000082646.2
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]
    pfam15898
    Location:873 → 971
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cl26073
    Location:52 → 310
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_024991985.2 → XP_024847753.1  protein phosphatase 1 regulatory subunit 12A isoform X5

    UniProtKB/TrEMBL
    A0A3Q1MLL6
    Related
    ENSBTAP00000019454.7, ENSBTAT00000019454.7
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]
    pfam15898
    Location:870 → 968
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cl26073
    Location:52 → 310
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_024991981.2 → XP_024847749.1  protein phosphatase 1 regulatory subunit 12A isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MLL6, E1BC59
    Related
    ENSBTAP00000070203.2, ENSBTAT00000082779.2
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]
    pfam15898
    Location:929 → 1027
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cl26073
    Location:52 → 310
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_024991983.2 → XP_024847751.1  protein phosphatase 1 regulatory subunit 12A isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MLL6
    Related
    ENSBTAP00000053760.4, ENSBTAT00000061600.4
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]
    pfam15898
    Location:929 → 983
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cl26073
    Location:52 → 310
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_059886596.1 → XP_059742579.1  protein phosphatase 1 regulatory subunit 12A isoform X3

RNA

  1. XR_009494419.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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