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Llgl1 LLGL scribble cell polarity complex component 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54265, updated on 13-Apr-2024

Summary

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Official Symbol
Llgl1provided by RGD
Official Full Name
LLGL scribble cell polarity complex component 1provided by RGD
Primary source
RGD:3012
See related
Ensembl:ENSRNOG00000003948 AllianceGenome:RGD:3012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LLGL; Mgl1; Rgl1; Llglh; Rgl-1
Summary
Enables GTPase activator activity and small GTPase binding activity. Involved in Golgi to plasma membrane transport and axonogenesis. Located in Golgi cis cisterna; early endosome membrane; and trans-Golgi network membrane. Colocalizes with axon. Orthologous to human LLGL1 (LLGL scribble cell polarity complex component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 76.9), Thymus (RPKM 65.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Llgl1 in Genome Data Viewer
Location:
10q22
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45878936..45893609)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45379423..45394096)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46940873..46955524)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene myosin XVA Neighboring gene alkB homolog 5, RNA demethylase Neighboring gene U7 small nuclear RNA Neighboring gene ribosomal protein L17 like 5 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene FLII, actin remodeling protein Neighboring gene mitochondrial elongation factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The rgl-1 is a legitimate homologue of lethal giant larvae recessive oncogene in rat. Kim YS, et al. Int J Oncol, 2002 Jun. PMID 12012002
  2. Proteome analysis of actin filament-associated proteins in the postnatal rat cerebellum. Shi N, et al. Neuroscience, 2012 Dec 27. PMID 23032931
  3. WD-40 repeat containing rat lethal giant larvae recessive oncogene, but not m-tomosyn, restores the salt sensitivity in Saccharomyces cerevisiae. Kim YS, et al. Int J Oncol, 2003 Jul. PMID 12792798
  4. A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain. Strand D, et al. Oncogene, 1995 Jul 20. PMID 7542763
  5. Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization. Wang T, et al. Dev Cell, 2011 Sep 13. PMID 21856246

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within maintenance of apical/basal cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi cis cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath abaxonal region ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lethal(2) giant larvae protein homolog 1
Names
LLGL1, scribble cell polarity complex component
lethal giant larvae homolog 1, scribble cell polarity complex component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304613.1 → NP_001291542.1  lethal(2) giant larvae protein homolog 1

    See identical proteins and their annotated locations for NP_001291542.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HF50, A6HF51, G3V6I1
    Related
    ENSRNOP00000005366.4, ENSRNOT00000005366.6
    Conserved Domains (2) summary
    pfam08366
    Location:279 → 378
    LLGL; LLGL2
    sd00039
    Location:38 → 73
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    45878936..45893609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246519.5 → XP_006246581.1  lethal(2) giant larvae protein homolog 1 isoform X1

    UniProtKB/TrEMBL
    A6HF51
    Conserved Domains (2) summary
    pfam08366
    Location:278 → 377
    LLGL; LLGL2
    sd00039
    Location:38 → 73
    7WD40; WD40 repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152844.1: Suppressed sequence

    Description
    NM_152844.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4K5.1 GenPept UniProtKB/Swiss-Prot:Q8K4K5

Gene LinkOut

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