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Sstr2 somatostatin receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54305, updated on 9-Dec-2024

Summary

Official Symbol
Sstr2provided by RGD
Official Full Name
somatostatin receptor 2provided by RGD
Primary source
RGD:3763
See related
EnsemblRapid:ENSRNOG00000002793 AllianceGenome:RGD:3763
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Smstr2
Summary
Enables PDZ domain binding activity and somatostatin receptor activity. Involved in several processes, including brain development; cellular response to estradiol stimulus; and peristalsis. Predicted to be located in cytosol and membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Predicted to be active in neuron projection and plasma membrane. Orthologous to human SSTR2 (somatostatin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 48.4), Brain (RPKM 31.2) and 3 other tissues See more
Orthologs
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Genomic context

See Sstr2 in Genome Data Viewer
Location:
10q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (99163353..99170519)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (98664204..98671370)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (102136283..102143449)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39, member 11 Neighboring gene uncharacterized LOC120095210 Neighboring gene transfer RNA alanine (anticodon UGC) 10 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene mitochondrial nucleoid associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding PubMed 
enables PDZ domain binding  
enables neuropeptide binding  
enables protein heterodimerization activity  
enables somatostatin receptor activity  
enables somatostatin receptor activity PubMed 
enables somatostatin receptor activity  
Component Evidence Code Pubs
part_of G protein-coupled receptor heterodimeric complex  
located_in cytosol  
located_in cytosol  
located_in membrane  
is_active_in neuron projection  
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
somatostatin receptor type 2
Names
SRIF-1
SS-2-R
SS2-R
SS2R
somatostatin receptor subtype 2
somatotropin release-inhibiting factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019348.2 → NP_062221.1  somatostatin receptor type 2

    See identical proteins and their annotated locations for NP_062221.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P30680
    UniProtKB/TrEMBL
    A6HKF9, A6HKG0
    Related
    ENSRNOP00000110504.1, ENSRNOT00000133830.1
    Conserved Domains (2) summary
    pfam00001
    Location:60 → 312
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:54 → 327
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    99163353..99170519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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