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Rassf5 Ras association domain family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54355, updated on 13-Apr-2024

Summary

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Official Symbol
Rassf5provided by RGD
Official Full Name
Ras association domain family member 5provided by RGD
Primary source
RGD:621694
See related
Ensembl:ENSRNOG00000005342 AllianceGenome:RGD:621694
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Maxp1; Nore1
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of cell population proliferation; positive regulation of protein ubiquitination; and regulation of protein localization to nucleus. Predicted to be located in cytoplasm and microtubule. Predicted to be active in nucleus. Orthologous to human RASSF5 (Ras association domain family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 158.5), Thymus (RPKM 152.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rassf5 in Genome Data Viewer
Location:
13q13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45189768..45255277, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (42637513..42703024, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47956754..48022333, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481556 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 3 Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene uncharacterized LOC134481557 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit epsilon Neighboring gene uncharacterized LOC120096246 Neighboring gene SLIT-ROBO Rho GTPase activating protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma. Shinmura K, et al. Lung Cancer, 2011 Jan. PMID 20434789
  2. Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase. Nakamura T, et al. Genes Cells, 2013 Nov. PMID 24165023
  3. Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1. Katagiri K, et al. Immunity, 2011 Jan 28. PMID 21194982
  4. The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. Vos MD, et al. J Biol Chem, 2003 Jun 13. PMID 12676952
  5. Ras signaling in NGF reduction and TNF-α-related pancreatic β cell apoptosis in hyperglycemic rats. Gezginci-Oktayoglu S, et al. Apoptosis, 2012 Jan. PMID 21938476

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. specific activation of Rap1B contributes to neuronal polarization via interaction with RalA and Nore1A in addition to PI3-kinase.
    Title: Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase.
  2. Apoptotic Ras effector molecules RASSF1 and NORE1 play important role in NGF reduction and TNF-alpha-related pancreatic beta cell apoptosis in hyperglycemic rats.
    Title: Ras signaling in NGF reduction and TNF-α-related pancreatic β cell apoptosis in hyperglycemic rats.
  3. Nore1 is a member of a family of Ras effector/tumor suppressors that includes RASSF1
    Title: The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras association domain-containing protein 5
Names
Ras association (RalGDS/AF-6) domain family member 5
new ras effector 1
novel ras effector 1
protein interacting with guanine nucleotide exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019365.4 → NP_062238.1  ras association domain-containing protein 5

    See identical proteins and their annotated locations for NP_062238.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    O35141
    UniProtKB/TrEMBL
    A6IC16
    Related
    ENSRNOP00000008055.3, ENSRNOT00000008055.6
    Conserved Domains (3) summary
    cd01778
    Location:267 → 360
    RASSF1_RA; Ubiquitin-like domain of RASSF1 tumour supproessor protein
    pfam16517
    Location:366 → 405
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00040
    Location:118 → 166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    45189768..45255277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769494.4 → XP_008767716.1  ras association domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JY99
    Related
    ENSRNOP00000070574.1
    Conserved Domains (2) summary
    cd01778
    Location:119 → 212
    RASSF1_RA; Ubiquitin-like domain of RASSF1 tumour supproessor protein
    pfam16517
    Location:218 → 257
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35141.1 GenPept UniProtKB/Swiss-Prot:O35141

Gene LinkOut

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