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Mtmr7 myotubularin related protein 7 [ Mus musculus (house mouse) ]

Gene ID: 54384, updated on 30-Apr-2024

Summary

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Official Symbol
Mtmr7provided by MGI
Official Full Name
myotubularin related protein 7provided by MGI
Primary source
MGI:MGI:1891693
See related
Ensembl:ENSMUSG00000039431 AllianceGenome:MGI:1891693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables inositol bisphosphate phosphatase activity. Acts upstream of or within inositol phosphate dephosphorylation and phosphatidylinositol dephosphorylation. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; central nervous system; integumental system; peripheral nervous system ganglion; and sensory organ. Orthologous to human MTMR7 (myotubularin related protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 9.2), CNS E18 (RPKM 9.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Mtmr7 in Genome Data Viewer
Location:
8 A4; 8 23.89 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41003184..41088210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40548199..40634935, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 7666 Neighboring gene mitochondrial calcium uptake family, member 3 Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene vacuolar protein sorting 37A Neighboring gene STARR-seq mESC enhancer starr_21271 Neighboring gene STARR-seq mESC enhancer starr_21272 Neighboring gene STARR-seq mESC enhancer starr_21273 Neighboring gene ADAM metallopeptidase domain 24 Neighboring gene high mobility group box 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling. Zhao D, et al. Cell Cycle, 2019 Oct. PMID 31478454, Free PMC Article
  2. Silencing myotubularin related protein 7 enhances proliferation and early differentiation of C2C12 myoblast. Yuan Z, et al. Biochem Biophys Res Commun, 2017 Mar 11. PMID 28153733
  3. Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and protein kinase B AKT signaling. Guo L, et al. Proc Natl Acad Sci U S A, 2013 May 14. PMID 23630283, Free PMC Article
  4. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. Mochizuki Y, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12890864, Free PMC Article
  5. Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development. Soehn AS, et al. Genesis, 2009 Oct. PMID 19621438

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
  2. MTMR7 suppresses the phenotypic switching of vascular smooth muscle cell and vascular intimal hyperplasia after injury via regulating p62/mTORC1-mediated glucose metabolism.
    Title: MTMR7 suppresses the phenotypic switching of vascular smooth muscle cell and vascular intimal hyperplasia after injury via regulating p62/mTORC1-mediated glucose metabolism.
  3. Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling.
    Title: Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling.
  4. The improved proliferation capacity was related to the increased phosphorylation of AKT. Taken together, our research demonstrates that MTMR7 plays an important role in proliferation and early differentiation of C2C12 myoblast.
    Title: Silencing myotubularin related protein 7 enhances proliferation and early differentiation of C2C12 myoblast.
  5. MTMR7 forms a complex with MTMR9 and dephosphorylates phosphatidylinositol 3-phosphate and Ins(1,3)P2 in neuronal cells.
    Title: Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol bisphosphate phosphatase activity EXP
Inferred from Experiment
more info
 PubMed 
enables phosphatidylinositol phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myotubularin-related protein 7
Names
inositol 1,3-bisphosphate phosphatase
phosphatidylinositol-3-phosphate phosphatase
NP_001035789.1
NP_001412577.1
XP_006509530.1
XP_006509532.1
XP_036010070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040699.2 → NP_001035789.1  myotubularin-related protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001035789.1

    Status: VALIDATED

    Source sequence(s)
    AC121140
    Consensus CDS
    CCDS40324.1
    UniProtKB/Swiss-Prot
    Q8C4J6, Q9Z2C9
    Related
    ENSMUSP00000043851.11, ENSMUST00000048898.17
    Conserved Domains (2) summary
    cd13344
    Location:1 → 103
    PH-GRAM_MTMR7; Myotubularian (MTM) related 7 protein (MTMR7) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam06602
    Location:109 → 446
    Myotub-related; Myotubularin-like phosphatase domain

  2. NM_001425648.1 → NP_001412577.1  myotubularin-related protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121140

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    41003184..41088210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154177.1 → XP_036010070.1  myotubularin-related protein 7 isoform X2

    Conserved Domains (1) summary
    cl28904
    Location:1 → 212
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_006509467.5 → XP_006509530.1  myotubularin-related protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006509530.1

    Conserved Domains (1) summary
    cl28904
    Location:1 → 212
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_006509469.5 → XP_006509532.1  myotubularin-related protein 7 isoform X3

    Conserved Domains (1) summary
    pfam06602
    Location:1 → 151
    Myotub-related; Myotubularin-like phosphatase domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019433.1: Suppressed sequence

    Description
    NM_019433.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2C9.2 GenPept UniProtKB/Swiss-Prot:Q9Z2C9

Gene LinkOut

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