Sit1 suppression inducing transmembrane adaptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sit1provided by MGI
Official Full Name: suppression inducing transmembrane adaptor 1provided by MGI
Primary source: MGI:MGI:1889342
See related: Ensembl:ENSMUSG00000028460 AllianceGenome:MGI:1889342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sit
Summary: Predicted to enable kinase binding activity. Predicted to be involved in regulation of T cell activation. Predicted to act upstream of or within adaptive immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human SIT1 (signaling threshold regulating transmembrane adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 61.9), spleen adult (RPKM 7.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 23.04 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43482083..43483709, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43482083..43483709, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIT and LAX are important negative regulators of immune responses that functionally cooperate.
Title: Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX.
SIT as an important modulator of TCR-mediated signaling that regulates T-cell activation, homeostasis and tolerance
Title: The transmembrane adaptor protein SIT inhibits TCR-mediated signaling.
SIT and T cell receptor-interacting molecule (TRIM) regulate cell fate of developing thymocytes and are essential regulators of central tolerance.
Title: SIT and TRIM determine T cell fate in the thymus.
SIT negatively regulates T cell homeostasis.
Title: Regulation of T cell homeostasis by the transmembrane adaptor protein SIT.
SIT is a critical negative regulator of T-cell receptor-mediated signaling
Title: The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signaling threshold-regulating transmembrane adapter 1

Names: SHP2 interacting transmembrane adaptor protein; SHP2-interacting transmembrane adapter protein; suppression-inducing transmembrane adapter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.