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Dll4 delta like canonical Notch ligand 4 [ Mus musculus (house mouse) ]

Gene ID: 54485, updated on 4-Jan-2025

Summary

Official Symbol
Dll4provided by MGI
Official Full Name
delta like canonical Notch ligand 4provided by MGI
Primary source
MGI:MGI:1859388
See related
Ensembl:ENSMUSG00000027314 AllianceGenome:MGI:1859388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Delta4
Summary
Enables Notch binding activity. Involved in several processes, including blood vessel remodeling; circulatory system development; and regulation of Notch signaling pathway. Acts upstream of or within several processes, including Notch signaling pathway; angiogenesis; and negative regulation of blood vessel endothelial cell migration. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; intestine; and retina. Used to study Adams-Oliver syndrome. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in lung adult (RPKM 41.8), subcutaneous fat pad adult (RPKM 15.0) and 16 other tissues See more
Orthologs
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Genomic context

See Dll4 in Genome Data Viewer
Location:
2 E5; 2 59.97 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119156286..119166145)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119325784..119335666)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:119125812-119126013 Neighboring gene VPS18 CORVET/HOPS core subunit Neighboring gene predicted gene, 52558 Neighboring gene predicted gene 14207 Neighboring gene STARR-positive B cell enhancer ABC_E4493 Neighboring gene STARR-positive B cell enhancer ABC_E1251 Neighboring gene ChaC, cation transport regulator 1 Neighboring gene INO80 complex subunit Neighboring gene STARR-seq mESC enhancer starr_05481 Neighboring gene STARR-positive B cell enhancer ABC_E5969 Neighboring gene STARR-seq mESC enhancer starr_05483

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding  
enables Notch binding PubMed 
enables Notch binding PubMed 
enables Notch binding  
enables calcium ion binding  
enables protein binding PubMed 
enables receptor ligand activity  
enables receptor ligand activity  
Items 1 - 25 of 44
Process Evidence Code Pubs
involved_in Notch signaling pathway  
acts_upstream_of_or_within Notch signaling pathway PubMed 
involved_in Notch signaling pathway PubMed 
involved_in Notch signaling pathway  
involved_in T cell differentiation PubMed 
acts_upstream_of_or_within angiogenesis PubMed 
involved_in aortic valve morphogenesis  
involved_in aortic valve morphogenesis  
involved_in blood vessel lumenization PubMed 
involved_in blood vessel remodeling PubMed 
involved_in branching involved in blood vessel morphogenesis PubMed 
involved_in cardiac atrium morphogenesis PubMed 
involved_in cardiac ventricle morphogenesis PubMed 
involved_in cellular response to fibroblast growth factor stimulus  
involved_in cellular response to fibroblast growth factor stimulus  
involved_in cellular response to vascular endothelial growth factor stimulus  
involved_in cellular response to vascular endothelial growth factor stimulus  
involved_in dorsal aorta morphogenesis PubMed 
involved_in negative regulation of Notch signaling pathway  
involved_in negative regulation of Notch signaling pathway PubMed 
acts_upstream_of_or_within negative regulation of blood vessel endothelial cell migration PubMed 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
involved_in negative regulation of cell migration involved in sprouting angiogenesis  
involved_in negative regulation of cell migration involved in sprouting angiogenesis  
involved_in negative regulation of cell population proliferation  
involved_in negative regulation of cell population proliferation  
involved_in negative regulation of endothelial cell migration  
involved_in negative regulation of endothelial cell migration  
involved_in negative regulation of gene expression  
involved_in negative regulation of gene expression  
involved_in negative regulation of transcription by RNA polymerase II PubMed 
involved_in pericardium morphogenesis PubMed 
involved_in positive regulation of Notch signaling pathway PubMed 
involved_in positive regulation of gene expression  
acts_upstream_of positive regulation of gene expression  
involved_in positive regulation of gene expression  
involved_in positive regulation of neural precursor cell proliferation PubMed 
involved_in regulation of neural retina development PubMed 
acts_upstream_of_or_within regulation of neurogenesis PubMed 
involved_in ventral spinal cord interneuron fate commitment  
involved_in ventral spinal cord interneuron fate commitment  
involved_in ventricular trabecula myocardium morphogenesis PubMed 
involved_in visual perception  
Items 1 - 25 of 44
Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
delta-like protein 4
Names
delta-like 4
drosophila Delta homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019454.4NP_062327.2  delta-like protein 4 precursor

    See identical proteins and their annotated locations for NP_062327.2

    Status: VALIDATED

    Source sequence(s)
    AL929318
    Consensus CDS
    CCDS16600.1
    UniProtKB/Swiss-Prot
    Q9DBU9, Q9JHZ7, Q9JI71
    Related
    ENSMUSP00000099575.4, ENSMUST00000102517.4
    Conserved Domains (3) summary
    cd00054
    Location:329361
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:156218
    DSL; Delta serrate ligand
    pfam07657
    Location:2889
    MNNL; N terminus of Notch ligand

RNA

  1. NR_185308.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL929318
  2. NR_185309.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL929318

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119156286..119166145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251887.2XP_030107747.1  delta-like protein 4 isoform X1

    Conserved Domains (1) summary
    cd00054
    Location:239274
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
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