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SGTB small glutamine rich tetratricopeptide repeat co-chaperone beta [ Homo sapiens (human) ]

Gene ID: 54557, updated on 7-Apr-2024

Summary

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Official Symbol
SGTBprovided by HGNC
Official Full Name
small glutamine rich tetratricopeptide repeat co-chaperone betaprovided by HGNC
Primary source
HGNC:HGNC:23567
See related
Ensembl:ENSG00000197860 MIM:620526; AllianceGenome:HGNC:23567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGT2
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in positive regulation of chaperone-mediated protein folding; posttranslational protein targeting to endoplasmic reticulum membrane; and ubiquitin-dependent ERAD pathway. Predicted to be part of TRC complex. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 18.1), appendix (RPKM 4.3) and 19 other tissues See more
Orthologs
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Genomic context

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Location:
5q12.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (65665928..65723013, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (66487700..66547014, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (64961755..65017936, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22608 Neighboring gene RNA, U6 small nuclear 540, pseudogene Neighboring gene tripartite motif containing 23 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:64934876-64935323 Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene shieldin complex subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22609 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:65015266-65015462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16056 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:65018623-65019444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16059 Neighboring gene PRAME family member 17 pseudogene Neighboring gene neurolysin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16060 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:65220503-65221127 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:65221752-65222376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22612 Neighboring gene LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene Neighboring gene erbb2 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bioinformatics identification of miR-514b-5p promotes NSCLC progression and induces PI3K/AKT and p38 pathways by targeting small glutamine-rich tetratricopeptide repeat-containing protein beta. Shi L, et al. FEBS J, 2023 Feb. PMID 36180981
  2. miRNA-365b promotes hepatocellular carcinoma cell migration and invasion by downregulating SGTB. Tian Q, et al. Future Oncol, 2019 Jun. PMID 30943053
  3. Up-regulation of SGTB is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide. Cao M, et al. J Mol Histol, 2013 Oct. PMID 23820636
  4. Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines. Heavner GA, et al. Regul Pept, 1990 Feb 4. PMID 2158125
  5. SGTb regulates a surface localization of a guidance receptor BOC to promote neurite outgrowth. Vuong TA, et al. Cell Signal, 2019 Mar. PMID 30639199

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamic stability of Sgt2 enables selective and privileged client handover in a chaperone triad.
    Title: Dynamic stability of Sgt2 enables selective and privileged client handover in a chaperone triad.
  2. Bioinformatics identification of miR-514b-5p promotes NSCLC progression and induces PI3K/AKT and p38 pathways by targeting small glutamine-rich tetratricopeptide repeat-containing protein beta.
    Title: Bioinformatics identification of miR-514b-5p promotes NSCLC progression and induces PI3K/AKT and p38 pathways by targeting small glutamine-rich tetratricopeptide repeat-containing protein beta.
  3. miR-365b promoted hepatocellular carcinoma (HCC) cell motility and spreading. Furthermore, SGTB was found to be a downstream target of miR-365b, and knockdown of the SGTB gene could mimic the effect of miR-365b in hastening HCC cell migration and invasion. These results imply that miR-365b plays a tumor-promoting role in HCC by suppressing SGTB expression.
    Title: miRNA-365b promotes hepatocellular carcinoma cell migration and invasion by downregulating SGTB.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein heterooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TRC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
small glutamine-rich tetratricopeptide repeat-containing protein beta
Names
beta-SGT
small glutamine rich protein with tetratricopeptide repeats 2
small glutamine rich tetratricopeptide repeat containing beta
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019072.3 → NP_061945.1  small glutamine-rich tetratricopeptide repeat-containing protein beta

    See identical proteins and their annotated locations for NP_061945.1

    Status: VALIDATED

    Source sequence(s)
    AC008560, AL713334, BC012044
    Consensus CDS
    CCDS3988.1
    UniProtKB/Swiss-Prot
    Q96EQ0
    Related
    ENSP00000370395.4, ENST00000381007.9
    Conserved Domains (3) summary
    sd00006
    Location:85 → 113
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:5 → 64
    SGTA_dimer; Homodimerisation domain of SGTA
    cl26005
    Location:85 → 237
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    65665928..65723013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248548.4 → XP_005248605.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X1

    See identical proteins and their annotated locations for XP_005248605.1

    UniProtKB/Swiss-Prot
    Q96EQ0
    Conserved Domains (3) summary
    sd00006
    Location:85 → 113
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:5 → 64
    SGTA_dimer; Homodimerisation domain of SGTA
    cl26005
    Location:85 → 237
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

  2. XM_047417334.1 → XP_047273290.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    66487700..66547014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352854.1 → XP_054208829.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X1

    UniProtKB/Swiss-Prot
    Q96EQ0

  2. XM_054352855.1 → XP_054208830.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96EQ0.1 GenPept UniProtKB/Swiss-Prot:Q96EQ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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