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DLL4 delta like canonical Notch ligand 4 [ Homo sapiens (human) ]

Gene ID: 54567, updated on 4-Jan-2025

Summary

Official Symbol
DLL4provided by HGNC
Official Full Name
delta like canonical Notch ligand 4provided by HGNC
Primary source
HGNC:HGNC:2910
See related
Ensembl:ENSG00000128917 MIM:605185; AllianceGenome:HGNC:2910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AOS6; delta4; hdelta2
Summary
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 11.5), fat (RPKM 11.2) and 22 other tissues See more
Orthologs
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Genomic context

See DLL4 in Genome Data Viewer
Location:
15q15.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40929340..40939073)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38735323..38745058)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41221538..41231271)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9270 Neighboring gene VPS18 core subunit of CORVET and HOPS complexes Neighboring gene Sharpr-MPRA regulatory region 6315 Neighboring gene uncharacterized LOC105370943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41207495-41208162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41217384-41218229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41230399-41231215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6353 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41244878-41245471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41247897-41248447 Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Adams-Oliver syndrome 6
MedGen: C4225271 OMIM: 616589 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC126344

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Notch binding  
enables Notch binding PubMed 
enables calcium ion binding  
enables protein binding PubMed 
enables receptor ligand activity PubMed 
Items 1 - 25 of 34
Process Evidence Code Pubs
involved_in Notch signaling pathway  
involved_in Notch signaling pathway PubMed 
involved_in Notch signaling pathway  
involved_in T cell differentiation  
involved_in angiogenesis  
involved_in aortic valve morphogenesis PubMed 
involved_in blood vessel lumenization  
involved_in blood vessel remodeling  
involved_in branching involved in blood vessel morphogenesis  
involved_in cardiac atrium morphogenesis  
involved_in cardiac ventricle morphogenesis  
involved_in cellular response to fibroblast growth factor stimulus PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus PubMed 
involved_in dorsal aorta morphogenesis  
involved_in negative regulation of Notch signaling pathway  
involved_in negative regulation of Notch signaling pathway  
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis PubMed 
involved_in negative regulation of cell migration involved in sprouting angiogenesis PubMed 
involved_in negative regulation of cell migration involved in sprouting angiogenesis PubMed 
involved_in negative regulation of cell population proliferation PubMed 
involved_in negative regulation of endothelial cell migration PubMed 
involved_in negative regulation of gene expression PubMed 
involved_in negative regulation of transcription by RNA polymerase II  
involved_in pericardium morphogenesis  
involved_in positive regulation of Notch signaling pathway  
acts_upstream_of positive regulation of gene expression PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of neural precursor cell proliferation  
involved_in regulation of neural retina development  
involved_in regulation of neurogenesis  
involved_in signal transduction PubMed 
involved_in ventral spinal cord interneuron fate commitment PubMed 
involved_in ventricular trabecula myocardium morphogenesis  
involved_in visual perception  
Items 1 - 25 of 34
Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
delta-like protein 4
Names
delta 4
delta ligand 4
delta-like 4 homolog
delta-like 4 protein
drosophila Delta homolog 4
notch ligand DLL4
notch ligand delta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046974.1 RefSeqGene

    Range
    5008..14741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1268

mRNA and Protein(s)

  1. NM_019074.4NP_061947.1  delta-like protein 4 precursor

    See identical proteins and their annotated locations for NP_061947.1

    Status: REVIEWED

    Source sequence(s)
    AB036931, AI478830, BC106950, DA089757, HY291308
    Consensus CDS
    CCDS45232.1
    UniProtKB/Swiss-Prot
    Q3KP23, Q9NQT9, Q9NR61
    UniProtKB/TrEMBL
    B2R9L8
    Related
    ENSP00000249749.5, ENST00000249749.7
    Conserved Domains (3) summary
    cd00054
    Location:327360
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:155217
    DSL; Delta serrate ligand
    pfam07657
    Location:2788
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    40929340..40939073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    38735323..38745058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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