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Mast3 microtubule associated serine/threonine kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 546071, updated on 30-Apr-2024

Summary

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Official Symbol
Mast3provided by MGI
Official Full Name
microtubule associated serine/threonine kinase 3provided by MGI
Primary source
MGI:MGI:2683541
See related
Ensembl:ENSMUSG00000031833 AllianceGenome:MGI:2683541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0561
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization; intracellular signal transduction; and peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human MAST3 (microtubule associated serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 51.9), cortex adult (RPKM 30.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Mast3 in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71230761..71257681, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70778117..70805048, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10506 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene RIKEN cDNA 2010320M18 gene Neighboring gene STARR-positive B cell enhancer ABC_E8241 Neighboring gene STARR-positive B cell enhancer ABC_E6649 Neighboring gene STARR-positive B cell enhancer ABC_E2265 Neighboring gene microRNA 7240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73330531-73330714 Neighboring gene interleukin 12 receptor, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E133 Neighboring gene arrestin domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pathogenic MAST3 Variants in the STK Domain Are Associated with Epilepsy. Spinelli E, et al. Ann Neurol, 2021 Aug. PMID 34185323, Free PMC Article
  2. MAST3: a novel IBD risk factor that modulates TLR4 signaling. Labbé C, et al. Genes Immun, 2008 Oct. PMID 18650832, Free PMC Article
  3. ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase). Andrade EC, et al. J Neurosci, 2017 Mar 8. PMID 28167675, Free PMC Article
  4. Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations. Tripathy R, et al. Neuron, 2018 Dec 19. PMID 30449657, Free PMC Article
  5. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransmitter dopamine acting on these cells. We find that the protein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3.
    Title: ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase).
  2. As in human immune cells, murine Mast3 is constitutively expressed in CD4-positive and CD8-positive T cells and CD19-expressing B cells.
    Title: MAST3: a novel IBD risk factor that modulates TLR4 signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
microtubule-associated serine/threonine-protein kinase 3
NP_001389902.1
NP_001389903.1
NP_001389904.1
NP_001389905.1
NP_001389907.1
NP_001389908.1
NP_001389909.1
NP_955012.2
XP_006509771.2
XP_006509772.2
XP_006509773.2
XP_006509775.1
XP_017168397.2
XP_017168398.1
XP_036010079.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402973.1 → NP_001389902.1  microtubule-associated serine/threonine-protein kinase 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC162446

  2. NM_001402974.1 → NP_001389903.1  microtubule-associated serine/threonine-protein kinase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162446
    UniProtKB/Swiss-Prot
    E9QQ28, Q3U214, Q6A047
    Related
    ENSMUSP00000128703.3, ENSMUST00000166004.3

  3. NM_001402975.1 → NP_001389904.1  microtubule-associated serine/threonine-protein kinase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC162446

  4. NM_001402976.1 → NP_001389905.1  microtubule-associated serine/threonine-protein kinase 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162446

  5. NM_001402978.1 → NP_001389907.1  microtubule-associated serine/threonine-protein kinase 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162446

  6. NM_001402979.1 → NP_001389908.1  microtubule-associated serine/threonine-protein kinase 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162446

  7. NM_001402980.1 → NP_001389909.1  microtubule-associated serine/threonine-protein kinase 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162446

  8. NM_199308.3 → NP_955012.2  microtubule-associated serine/threonine-protein kinase 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC162446
    Consensus CDS
    CCDS52577.1
    UniProtKB/TrEMBL
    A0A1D5RM97
    Related
    ENSMUSP00000148686.2, ENSMUST00000211948.2
    Conserved Domains (4) summary
    smart00220
    Location:373 → 646
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:955 → 1032
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:372 → 651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64 → 337
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71230761..71257681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154186.1 → XP_036010079.1  microtubule-associated serine/threonine-protein kinase 3 isoform X11

    Conserved Domains (3) summary
    cd00992
    Location:955 → 1032
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:372 → 651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57 → 337
    DUF1908; Domain of unknown function (DUF1908)

  2. XM_017312908.2 → XP_017168397.2  microtubule-associated serine/threonine-protein kinase 3 isoform X10

    Conserved Domains (3) summary
    cd00992
    Location:956 → 1033
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:373 → 652
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:58 → 338
    DUF1908; Domain of unknown function (DUF1908)

  3. XM_006509710.3 → XP_006509773.2  microtubule-associated serine/threonine-protein kinase 3 isoform X5

    Conserved Domains (3) summary
    cd00992
    Location:978 → 1055
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:395 → 674
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:87 → 360
    DUF1908; Domain of unknown function (DUF1908)

  4. XM_006509708.3 → XP_006509771.2  microtubule-associated serine/threonine-protein kinase 3 isoform X2

    Conserved Domains (3) summary
    cd00992
    Location:985 → 1062
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:402 → 681
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:87 → 367
    DUF1908; Domain of unknown function (DUF1908)

  5. XM_006509709.4 → XP_006509772.2  microtubule-associated serine/threonine-protein kinase 3 isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:979 → 1056
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:396 → 675
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:88 → 361
    DUF1908; Domain of unknown function (DUF1908)

  6. XM_017312909.2 → XP_017168398.1  microtubule-associated serine/threonine-protein kinase 3 isoform X4

    Conserved Domains (3) summary
    smart00228
    Location:974 → 1055
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:395 → 674
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:80 → 360
    DUF1908; Domain of unknown function (DUF1908)

  7. XM_006509712.5 → XP_006509775.1  microtubule-associated serine/threonine-protein kinase 3 isoform X9

    Conserved Domains (3) summary
    cd00992
    Location:961 → 1038
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:378 → 657
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:63 → 343
    DUF1908; Domain of unknown function (DUF1908)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U214.3 GenPept UniProtKB/Swiss-Prot:Q3U214

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