U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PVX_089950 bifunctional dihydrofolate reductase-thymidylate synthase 1, putative [ Plasmodium vivax (malaria parasite P. vivax) ]

Gene ID: 5474373, updated on 16-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
PVX_089950
Gene description
bifunctional dihydrofolate reductase-thymidylate synthase 1, putative
Locus tag
PVX_089950
Gene type
protein coding
RNA name
bifunctional dihydrofolate reductase-thymidylate synthase 1, putative
RefSeq status
PROVISIONAL
Organism
Plasmodium vivax (strain: Salvador I)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Plasmodium)
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_009910.1 (964590..966469)

Chromosome 5 - NC_009910.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein, conserved Neighboring gene RNA-binding protein of pumilio/mpt5 family, putative Neighboring gene hypothetical protein, conserved Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_009910.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax. Chanama M, et al. Mol Biol Rep, 2011 Feb. PMID 20577818
  2. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Carlton JM, et al. Nature, 2008 Oct 9. PMID 18843361, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the TS subunit interface between Plasmodium species is sufficiently conserved to allow formation of fully active cross-species heterodimer
    Title: Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables dihydrofolate reductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables thymidylate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dTMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
bifunctional dihydrofolate reductase-thymidylate synthase 1, putative
XP_001615082.1
  • encoded by transcript PVX_089950A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009910.1 Reference assembly

    Range
    964590..966469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001615032.1 → XP_001615082.1  bifunctional dihydrofolate reductase-thymidylate synthase 1, putative [Plasmodium vivax]

    See identical proteins and their annotated locations for XP_001615082.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0J9THW1, A0A1G4H943, A5K620, C3RUA8
    Conserved Domains (3) summary
    cd00209
    Location:37 → 235
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
    PTZ00164
    Location:1 → 624
    PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional
    pfam00303
    Location:342 → 623
    Thymidylat_synt; Thymidylate synthase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials