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DCUN1D2 defective in cullin neddylation 1 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 55208, updated on 3-Apr-2024

Summary

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Official Symbol
DCUN1D2provided by HGNC
Official Full Name
defective in cullin neddylation 1 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20328
See related
Ensembl:ENSG00000150401 AllianceGenome:HGNC:20328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCNL2; C13orf17
Summary
Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart (RPKM 8.1), testis (RPKM 2.5) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
13q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113455819..113491563, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (112714662..112750406, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114110134..114145026, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114032969-114033953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114047778-114048319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5546 Neighboring gene Sharpr-MPRA regulatory region 10007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114059695-114060489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114061607-114062292 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114064726-114065925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114071164-114072164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114072165-114073165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114075358-114076070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114076783-114077494 Neighboring gene ADP-ribosylhydrolase like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114080191-114080738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114085068-114085648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114100205-114101146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114105835-114106336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114110333-114111263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5548 Neighboring gene RNA, U1 small nuclear 16, pseudogene Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114192765-114192953 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:114195260-114196459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114200259-114201002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114206049-114206550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114236917-114237890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114237891-114238862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114240840-114241440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114251630-114252130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114267642-114268206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114268207-114268770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269335-114269898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269899-114270462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271027-114271590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271591-114272153 Neighboring gene transcription factor Dp-1 Neighboring gene uncharacterized LOC124903219 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114279174-114280373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114305936-114306560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114306561-114307185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114311832-114312332 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene G protein-coupled receptor kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. Monda JK, et al. Structure, 2013 Jan 8. PMID 23201271, Free PMC Article
  2. The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Meyer-Schaller N, et al. Proc Natl Acad Sci U S A, 2009 Jul 28. PMID 19617556, Free PMC Article
  3. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. Keuss MJ, et al. J Cell Sci, 2016 Apr 1. PMID 26906416, Free PMC Article
  4. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Kurz T, et al. Nature, 2005 Jun 30. PMID 15988528
  5. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. Charlaftis N, et al. EMBO J, 2014 Nov 3. PMID 25260751, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10704, FLJ20092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein neddylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein neddylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DCN1-like protein 2
Names
DCN1, defective in cullin neddylation 1, domain containing 2
DCUN1 domain-containing protein 2
defective in cullin neddylation protein 1-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014283.2 → NP_001014305.1  DCN1-like protein 2

    See identical proteins and their annotated locations for NP_001014305.1

    Status: VALIDATED

    Source sequence(s)
    AK000099, AK001566, AL442125, BM836766
    Consensus CDS
    CCDS32013.1
    UniProtKB/Swiss-Prot
    Q5JSA5, Q5JSA6, Q5JSA7, Q6PH85, Q9NVJ1, Q9NXR6
    Related
    ENSP00000417706.1, ENST00000478244.6
    Conserved Domains (2) summary
    cd14412
    Location:2 → 48
    UBA_DCNL2; UBA-like domain found in DCN1-like protein 2 (DCNL2) and similar proteins
    pfam03556
    Location:136 → 246
    Cullin_binding; Cullin binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    113455819..113491563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020647.2 → XP_016876136.1  DCN1-like protein 2 isoform X2

    Conserved Domains (2) summary
    pfam03556
    Location:121 → 231
    Cullin_binding; Cullin binding
    cl21463
    Location:1 → 33
    UBA_like_SF; UBA domain-like superfamily

  2. XM_017020649.2 → XP_016876138.2  DCN1-like protein 2 isoform X3

    Related
    ENSP00000330629.3, ENST00000332592.7

  3. XM_017020644.2 → XP_016876133.1  DCN1-like protein 2 isoform X2

    Conserved Domains (2) summary
    pfam03556
    Location:121 → 231
    Cullin_binding; Cullin binding
    cl21463
    Location:1 → 33
    UBA_like_SF; UBA domain-like superfamily

  4. XM_017020643.2 → XP_016876132.1  DCN1-like protein 2 isoform X1

  5. XM_017020646.3 → XP_016876135.1  DCN1-like protein 2 isoform X2

    Conserved Domains (2) summary
    pfam03556
    Location:121 → 231
    Cullin_binding; Cullin binding
    cl21463
    Location:1 → 33
    UBA_like_SF; UBA domain-like superfamily

  6. XM_047430432.1 → XP_047286388.1  DCN1-like protein 2 isoform X2

  7. XM_047430431.1 → XP_047286387.1  DCN1-like protein 2 isoform X2

RNA

  1. XR_007063687.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    112714662..112750406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374656.1 → XP_054230631.1  DCN1-like protein 2 isoform X2

  2. XM_054374657.1 → XP_054230632.1  DCN1-like protein 2 isoform X3

  3. XM_054374654.1 → XP_054230629.1  DCN1-like protein 2 isoform X2

  4. XM_054374651.1 → XP_054230626.1  DCN1-like protein 2 isoform X1

  5. XM_054374655.1 → XP_054230630.1  DCN1-like protein 2 isoform X2

  6. XM_054374653.1 → XP_054230628.1  DCN1-like protein 2 isoform X2

  7. XM_054374652.1 → XP_054230627.1  DCN1-like protein 2 isoform X2

RNA

  1. XR_008488769.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018185.2: Suppressed sequence

    Description
    NM_018185.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PH85.1 GenPept UniProtKB/Swiss-Prot:Q6PH85

Gene LinkOut

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