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PPP3CC protein phosphatase 3 catalytic subunit gamma [ Homo sapiens (human) ]

Gene ID: 5533, updated on 4-Jan-2025

Summary

Official Symbol
PPP3CCprovided by HGNC
Official Full Name
protein phosphatase 3 catalytic subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:9316
See related
Ensembl:ENSG00000120910 MIM:114107; AllianceGenome:HGNC:9316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNA3; CALNA3; PP2Bgamma
Summary
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Broad expression in testis (RPKM 12.3), lymph node (RPKM 5.3) and 24 other tissues See more
Orthologs
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Genomic context

See PPP3CC in Genome Data Viewer
Location:
8p21.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22441078..22541125)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22714907..22814982)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22298591..22398638)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22250571-22251133 Neighboring gene ribosomal protein L21 pseudogene 77 Neighboring gene MPRA-validated peak6937 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18986 Neighboring gene RNA, U6 small nuclear 336, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27079 Neighboring gene uncharacterized LOC124901905 Neighboring gene BTF3 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22406579-22407079 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22408405-22409369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22409593-22410470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22410471-22411346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22413914-22414436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18990 Neighboring gene Sharpr-MPRA regulatory region 12029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22421349-22422242 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22429393-22430084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22430085-22430775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22431841-22432559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22435755-22436448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22439222-22439914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22442189-22442858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22447071-22448071 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22454615-22455362 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22455363-22456110 Neighboring gene PDZ and LIM domain 2

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host determinants of HIV-1 control in African Americans.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
enables calcium-dependent protein serine/threonine phosphatase activity PubMed 
enables calmodulin binding  
enables calmodulin-dependent protein phosphatase activity  
enables calmodulin-dependent protein phosphatase activity PubMed 
enables histone H2AXS140 phosphatase activity  
enables metal ion binding  
enables myosin phosphatase activity  
enables protein binding PubMed 
Component Evidence Code Pubs
part_of calcineurin complex  
part_of calcineurin complex PubMed 
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol PubMed 
located_in cytosol  
located_in glutamatergic synapse  
located_in mitochondrion  
located_in presynapse  
part_of protein serine/threonine phosphatase complex PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Names
CAM-PRP catalytic subunit
calcineurin, testis-specific catalytic subunit
protein phosphatase 3, catalytic subunit, gamma isozyme
NP_001230903.1
NP_001230904.1
NP_005596.2
XP_047277897.1
XP_047277898.1
XP_054216746.1
XP_054216747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243974.2NP_001230903.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1

    See identical proteins and their annotated locations for NP_001230903.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC037459, AK055013, AK299415, AY007249
    Consensus CDS
    CCDS59093.1
    UniProtKB/Swiss-Prot
    P48454
    Related
    ENSP00000380878.3, ENST00000397775.7
    Conserved Domains (2) summary
    smart00156
    Location:54325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain
  2. NM_001243975.2NP_001230904.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3

    See identical proteins and their annotated locations for NP_001230904.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) lacks two alternate internal segments compared to isoform 1.
    Source sequence(s)
    AK055013, AK299415, AY007249, S46622
    Consensus CDS
    CCDS59094.1
    UniProtKB/Swiss-Prot
    P48454
    Related
    ENSP00000289963.8, ENST00000289963.12
    Conserved Domains (2) summary
    smart00156
    Location:54325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain
  3. NM_005605.5NP_005596.2  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

    See identical proteins and their annotated locations for NP_005596.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK055013, AY007249, BC004864
    Consensus CDS
    CCDS34859.1
    UniProtKB/Swiss-Prot
    B4DRT5, P48454, Q9BSS6, Q9H4M5
    Related
    ENSP00000240139.5, ENST00000240139.10
    Conserved Domains (1) summary
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    22441078..22541125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421941.1XP_047277897.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1

  2. XM_047421942.1XP_047277898.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2

RNA

  1. XR_007060744.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    22714907..22814982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360771.1XP_054216746.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1

  2. XM_054360772.1XP_054216747.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2

RNA

  1. XR_008487862.1 RNA Sequence

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