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PPP6C protein phosphatase 6 catalytic subunit [ Homo sapiens (human) ]

Gene ID: 5537, updated on 5-Jan-2025

Summary

Official Symbol
PPP6Cprovided by HGNC
Official Full Name
protein phosphatase 6 catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:9323
See related
Ensembl:ENSG00000119414 MIM:612725; AllianceGenome:HGNC:9323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP6; PP6C
Summary
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 20.0), fat (RPKM 18.6) and 25 other tissues See more
Orthologs
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Genomic context

See PPP6C in Genome Data Viewer
Location:
9q33.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (125146573..125189803, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137344915..137388140, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127908852..127952082, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene suppressor of cancer cell invasion Neighboring gene NANOG hESC enhancer GRCh37_chr9:127737373-127737931 Neighboring gene frataxin pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127806191-127806703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127806704-127807217 Neighboring gene uncharacterized LOC124902355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20274 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127951404-127952190 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127952191-127952977 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 2 Neighboring gene uncharacterized LOC105376271 Neighboring gene ribosomal protein SA pseudogene 76

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, protein phosphatase 6, catalytic subunit (PPP6C), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ92648, MGC12249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
enables calmodulin-dependent protein phosphatase activity  
enables histone H2AXS140 phosphatase activity  
enables metal ion binding  
enables myosin phosphatase activity  
enables protein binding PubMed 
enables protein serine/threonine phosphatase activity  
enables protein serine/threonine phosphatase activity PubMed 
enables protein serine/threonine phosphatase activity  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in mitochondrion  
located_in nucleoplasm  

General protein information

Preferred Names
serine/threonine-protein phosphatase 6 catalytic subunit
Names
serine/threonine protein phosphatase catalytic subunit
NP_001116827.1
NP_001116841.1
NP_002712.1
XP_011517149.1
XP_047279522.1
XP_047279523.1
XP_047279524.1
XP_054219214.1
XP_054219215.1
XP_054219216.1
XP_054219217.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123355.2NP_001116827.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform a

    See identical proteins and their annotated locations for NP_001116827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript; it encodes the longest isoform (a).
    Source sequence(s)
    AA251321, AL445930, BC006990, CB250498, DB037210, DC334216
    Consensus CDS
    CCDS48018.1
    UniProtKB/Swiss-Prot
    O00743
    Related
    ENSP00000392147.1, ENST00000451402.5
    Conserved Domains (1) summary
    cd07415
    Location:5326
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  2. NM_001123369.2NP_001116841.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform c

    See identical proteins and their annotated locations for NP_001116841.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one coding exon compared to variant 1 and encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AA251321, AL445930, BC006990, CB250498, DC369815
    Consensus CDS
    CCDS48019.1
    UniProtKB/Swiss-Prot
    O00743
    Related
    ENSP00000411744.1, ENST00000415905.5
    Conserved Domains (1) summary
    cd07415
    Location:5267
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  3. NM_002721.5NP_002712.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform b

    See identical proteins and their annotated locations for NP_002712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the coding region, compared to variant 1; it encodes a shorter isoform (b).
    Source sequence(s)
    AA251321, AL445930, BC006990, CB250498, DB037210
    Consensus CDS
    CCDS6861.1
    UniProtKB/Swiss-Prot
    B2R5V6, B7Z2W9, B7Z5K9, O00743, Q5U0A2, Q9UIC9
    UniProtKB/TrEMBL
    A0A024R861
    Related
    ENSP00000362648.4, ENST00000373547.9
    Conserved Domains (1) summary
    cd07415
    Location:5289
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    125146573..125189803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423566.1XP_047279522.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X1

  2. XM_047423568.1XP_047279524.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X3

  3. XM_011518847.4XP_011517149.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

    Conserved Domains (2) summary
    PTZ00239
    Location:15293
    PTZ00239; serine/threonine protein phosphatase 2A; Provisional
    cd07415
    Location:13277
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  4. XM_047423567.1XP_047279523.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    137344915..137388140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363239.1XP_054219214.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X1

  2. XM_054363242.1XP_054219217.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X3

  3. XM_054363240.1XP_054219215.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

  4. XM_054363241.1XP_054219216.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

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