map3k5 mitogen-activated protein kinase kinase kinase 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: map3k5provided by ZNC
Official Full Name: mitogen-activated protein kinase kinase kinase 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030827-3
See related: Ensembl:ENSDARG00000005416 AllianceGenome:ZFIN:ZDB-GENE-030827-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Ask1
Summary: Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within defense response to bacterium. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 20

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (3005539..3087115, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (2993688..3073675, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in cellular response to stress	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

Go to the top of the page Help

Preferred Names: mitogen-activated protein kinase kinase kinase 5

NP_001155222.1

EC 2.7.11.25

XP_021324097.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161750.1 → NP_001155222.1 mitogen-activated protein kinase kinase kinase 5

Status: PROVISIONAL

Source sequence(s)

BX248523

UniProtKB/TrEMBL

A0A8M1NUN7, E7F2L3

Related

ENSDARP00000046640.6, ENSDART00000046641.9

Conserved Domains (3) summary

smart00220
Location:674 → 927

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06624
Location:660 → 927

STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase

pfam13281
Location:152 → 531

DUF4071; Domain of unknown function (DUF4071)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

3005539..3087115 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468422.1 → XP_021324097.1 mitogen-activated protein kinase kinase kinase 5 isoform X1

UniProtKB/TrEMBL

A0A8M9P2K6

Related

ENSDARP00000126631.1, ENSDART00000152495.3

Conserved Domains (2) summary

cd06624
Location:652 → 919

STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase

pfam13281
Location:152 → 523

DUF4071; Domain of unknown function (DUF4071)