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casp10 caspase 10, apoptosis-related cysteine peptidase [ Danio rerio (zebrafish) ]

Gene ID: 557302, updated on 27-Mar-2024

Summary

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Official Symbol
casp10provided by ZNC
Official Full Name
caspase 10, apoptosis-related cysteine peptidaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070608-2
See related
Ensembl:ENSDARG00000070272 AllianceGenome:ZFIN:ZDB-GENE-070608-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
casp8l2
Summary
Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; and death effector domain binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Predicted to act upstream of or within proteolysis and regulation of apoptotic process. Predicted to be active in cytoplasm. Is expressed in floor plate; intestinal bulb; muscle cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome (multiple); breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and non-Hodgkin lymphoma. Orthologous to several human genes including CASP10 (caspase 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (1339175..1358686)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (1337264..1355821)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene disintegrin and metalloproteinase domain-containing protein 23-like Neighboring gene chemerin chemokine-like receptor 2 Neighboring gene protein kinase, interferon-inducible double stranded RNA dependent activator Neighboring gene oxysterol binding protein-like 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change. Sakamaki K, et al. Biochem Biophys Rep, 2015 Sep. PMID 29124180, Free PMC Article
  2. Early developmental exposure to pentachlorophenol causes alterations on mRNA expressions of caspase protease family in zebrafish embryos. Zhao J, et al. Chemosphere, 2017 Aug. PMID 28402832
  3. Characterization of the caspase family in zebrafish. Spead O, et al. PLoS One, 2018. PMID 29791492, Free PMC Article
  4. Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Zhou ZJ, et al. Front Cell Infect Microbiol, 2016. PMID 27471679, Free PMC Article
  5. Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging. Xu H, et al. Genes (Basel), 2020 Sep 24. PMID 32987694, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables death effector domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
caspase-10; caspase-8
Names
caspase 8, apoptosis-related cysteine peptidase, like 2
caspase-8b
XP_685430.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    1339175..1358686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_680338.9 → XP_685430.4  caspase-8

    UniProtKB/TrEMBL
    A0A8N7TEL0, E7EXV8
    Related
    ENSDARP00000024255.8, ENSDART00000014766.9
    Conserved Domains (4) summary
    cd00032
    Location:273 → 515
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08334
    Location:108 → 190
    DED_Caspase_8_10_r2; Death effector domain, repeat 2, of initator caspases 8 and 10
    cd08792
    Location:11 → 87
    DED_Caspase_8_10_r1; Death effector domain, repeat 1, of initator caspases 8 and 10
    pfam15376
    Location:200 → 256
    DUF4603; Domain of unknown function (DUF4603)
Nucleotide Protein Strain
Heading Accession and Version

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