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PKN1 protein kinase N1 [ Homo sapiens (human) ]

Gene ID: 5585, updated on 4-Jan-2025

Summary

Official Symbol
PKN1provided by HGNC
Official Full Name
protein kinase N1provided by HGNC
Primary source
HGNC:HGNC:9405
See related
Ensembl:ENSG00000123143 MIM:601032; AllianceGenome:HGNC:9405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA
Summary
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 39.4), fat (RPKM 30.1) and 25 other tissues See more
Orthologs
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Genomic context

See PKN1 in Genome Data Viewer
Location:
19p13.12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14433306..14471859)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14559936..14598492)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14544118..14582671)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10244 Neighboring gene adhesion G protein-coupled receptor E5 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:14507248-14508447 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:14512346-14513545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14515967-14516596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14516597-14517226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14166 Neighboring gene DExD-box helicase 39A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14544012-14544585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14544586-14545158 Neighboring gene Sharpr-MPRA regulatory region 2073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14555029-14555529 Neighboring gene Sharpr-MPRA regulatory region 3261 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14582511-14583159 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14586151-14586819 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:14587236-14587718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14589159-14589674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14590760-14591354 Neighboring gene prostaglandin E receptor 1 Neighboring gene GIPC PDZ domain containing family member 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Application of HIV-1 Tat transmembrane transport peptide to cells induces PKN1 gene and slightly represses two genes, ZCD1 and BSG PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC46204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
enables calcium,diacylglycerol-dependent serine/threonine kinase activity  
enables chromatin binding PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity  
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity  
enables histone H3T11 kinase activity PubMed 
enables histone binding PubMed 
enables histone deacetylase binding PubMed 
enables nuclear androgen receptor binding PubMed 
enables nuclear receptor coactivator activity PubMed 
enables nuclear receptor coactivator activity PubMed 
enables protein binding PubMed 
enables protein kinase C binding PubMed 
enables protein kinase activity PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables small GTPase binding PubMed 
Process Evidence Code Pubs
involved_in B cell apoptotic process  
involved_in B cell homeostasis  
involved_in chromatin remodeling  
involved_in epithelial cell migration PubMed 
involved_in hyperosmotic response  
involved_in intracellular signal transduction  
involved_in negative regulation of B cell proliferation  
involved_in positive regulation of DNA-templated transcription  
involved_in post-translational protein modification PubMed 
involved_in protein phosphorylation PubMed 
involved_in regulation of androgen receptor signaling pathway  
involved_in regulation of cell motility PubMed 
involved_in regulation of germinal center formation  
involved_in regulation of immunoglobulin production  
involved_in regulation of transcription by RNA polymerase II PubMed 
involved_in regulation of transcription by RNA polymerase II PubMed 
involved_in renal system process  
involved_in signal transduction PubMed 
involved_in spleen development  
Component Evidence Code Pubs
located_in cleavage furrow PubMed 
located_in cytoplasm PubMed 
located_in cytosol  
located_in endosome PubMed 
located_in midbody PubMed 
located_in nucleoplasm  
located_in nucleus PubMed 
part_of protein-containing complex PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase N1
Names
protease-activated kinase 1
protein kinase C-like 1
protein kinase C-like PKN
protein kinase C-related kinase 1
protein kinase PKN-alpha
serine-threonine kinase N
serine/threonine protein kinase N
NP_002732.3
NP_998725.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002741.5NP_002732.3  serine/threonine-protein kinase N1 isoform 2

    See identical proteins and their annotated locations for NP_002732.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at the 5' end compared to variant 1, which includes a part of the coding region. The resulting isoform (2) has a distinct and shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC008569
    Consensus CDS
    CCDS42513.1
    UniProtKB/Swiss-Prot
    A8K7W5, B2R9R4, B3KVN3, Q15143, Q16512, Q504U4, Q8IUV5, Q9UD44
    Related
    ENSP00000242783.7, ENST00000242783.11
    Conserved Domains (6) summary
    cd08687
    Location:389476
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:4698
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11630
    Location:121196
    HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    cd11636
    Location:205278
    HR1_PKN1_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    smart00220
    Location:615874
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:615939
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
  2. NM_213560.3NP_998725.1  serine/threonine-protein kinase N1 isoform 1

    See identical proteins and their annotated locations for NP_998725.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC008569
    Consensus CDS
    CCDS42514.1
    UniProtKB/Swiss-Prot
    Q16512
    Related
    ENSP00000343325.4, ENST00000342216.8
    Conserved Domains (6) summary
    cd08687
    Location:395482
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:52104
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11630
    Location:127202
    HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    cd11636
    Location:211284
    HR1_PKN1_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    smart00220
    Location:621880
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:621945
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    14433306..14471859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    14559936..14598492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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