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cftr CF transmembrane conductance regulator [ Danio rerio (zebrafish) ]

Gene ID: 559080, updated on 4-Jan-2025

Summary

Official Symbol
cftrprovided by ZNC
Official Full Name
CF transmembrane conductance regulatorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050517-20
See related
Ensembl:ENSDARG00000041107 AllianceGenome:ZFIN:ZDB-GENE-050517-20
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-270i2.2
Summary
Enables ATP binding activity; ATP hydrolysis activity; and chloride channel activity. Involved in Kupffer's vesicle development and heart development. Acts upstream of or within several processes, including Spemann organizer formation at the embryonic shield; defense response to other organism; and hemopoiesis. Located in apical plasma membrane. Is expressed in several structures, including Kupffer's vesicle; digestive system; forerunner cell group; head; and pleuroperitoneal region. Used to study cystic fibrosis and diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See cftr in Genome Data Viewer
Location:
chromosome: 18
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (20677184..20722548)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (20688118..20733482)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family member 2 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1 Neighboring gene cortactin binding protein 2 Neighboring gene uncharacterized LOC137488275

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ABC-type transporter activity  
enables ATP binding PubMed 
enables ATP binding  
enables ATP hydrolysis activity PubMed 
enables ATP hydrolysis activity  
enables ATP hydrolysis activity  
enables ATPase-coupled transmembrane transporter activity  
enables ATPase-coupled transmembrane transporter activity PubMed 
enables bicarbonate transmembrane transporter activity  
enables chloride channel activity PubMed 
enables chloride channel activity  
enables chloride channel activity  
enables intracellularly ATP-gated chloride channel activity  
enables intracellularly ATP-gated chloride channel activity  
enables isomerase activity  
enables nucleotide binding  
Process Evidence Code Pubs
acts_upstream_of_or_within Kupffer's vesicle development PubMed 
acts_upstream_of_or_within Kupffer's vesicle development PubMed 
involved_in Kupffer's vesicle development PubMed 
acts_upstream_of_or_within Spemann organizer formation at the embryonic shield PubMed 
acts_upstream_of_or_within T cell differentiation PubMed 
involved_in bicarbonate transport  
involved_in bicarbonate transport  
involved_in cellular response to forskolin  
involved_in chloride transmembrane transport  
involved_in chloride transmembrane transport  
acts_upstream_of_or_within chloride transport  
acts_upstream_of_or_within defense response to bacterium PubMed 
acts_upstream_of_or_within embryonic hemopoiesis PubMed 
acts_upstream_of_or_within germ cell migration PubMed 
involved_in heart development PubMed 
acts_upstream_of_or_within innate immune response PubMed 
acts_upstream_of_or_within lymphoid lineage cell migration into thymus PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport  
acts_upstream_of_or_within monoatomic ion transport  
involved_in multicellular organismal-level water homeostasis  
acts_upstream_of_or_within pancreas development PubMed 
acts_upstream_of_or_within regulation of neutrophil chemotaxis PubMed 
acts_upstream_of_or_within respiratory burst involved in defense response PubMed 
involved_in transepithelial water transport  
acts_upstream_of_or_within transmembrane transport  
Component Evidence Code Pubs
is_active_in apical plasma membrane  
located_in apical plasma membrane PubMed 
part_of chloride channel complex  
is_active_in cytosol  
located_in early endosome membrane  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum membrane  
located_in endosome  
located_in membrane PubMed 
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in recycling endosome membrane  

General protein information

Preferred Names
cystic fibrosis transmembrane conductance regulator
Names
ATP-binding cassette sub-family C member 7
abcc7
cAMP-dependent chloride channel
channel conductance-controlling ATPase
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NP_001038348.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044883.1NP_001038348.1  cystic fibrosis transmembrane conductance regulator

    Status: PROVISIONAL

    Source sequence(s)
    BX470130
    UniProtKB/Swiss-Prot
    B7ZVN9, Q1LX78
    Related
    ENSDARP00000060242.7, ENSDART00000060243.9
    Conserved Domains (1) summary
    cl28181
    Location:11485
    AAA; ATPases associated with a variety of cellular activities

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    20677184..20722548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395022.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    273654..319950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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