Slc13a1 solute carrier family 13 (sodium/sulfate symporters), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc13a1provided by MGI
Official Full Name: solute carrier family 13 (sodium/sulfate symporters), member 1provided by MGI
Primary source: MGI:MGI:1859937
See related: Ensembl:ENSMUSG00000029700 AllianceGenome:MGI:1859937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nas1; NaSi-1
Summary: Enables secondary active sulfate transmembrane transporter activity. Acts upstream of or within sulfate transport. Predicted to be integral component of plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human SLC13A1 (solute carrier family 13 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 87.6), large intestine adult (RPKM 38.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1; 6 11.22 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (24088282..24168118, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (24088283..24168119, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NaS1 is essential to maintain high maternal and fetal sulfate levels, which is important for maintaining pregnancy, placental development and normal birth weight
Title: Fetal loss and hyposulfataemia in pregnant NaS1 transporter null mice.
Enhanced tumor growth in the NaS1 sulfate transporter null mouse.
Title: Enhanced tumor growth in the NaS1 sulfate transporter null mouse.
NaS1 is essential for maintaining a normal metabolic state in the kidney and that loss of NaS1 function leads to reduced circulating steroid levels and increased urinary steroid excretion.
Title: Kidney transcriptome reveals altered steroid homeostasis in NaS1 sulfate transporter null mice.
Our data indicate that decreased circulating SO4 concentrations modulate 5-HT neurotransmitter and receptor levels, in a manner consistent with the behavioural phenotypes of Nas1 mice.
Title: Hyperserotonaemia and reduced brain serotonin levels in NaS1 sulphate transporter null mice.
NaS1 has a role in lipid and cholesterol metabolism
Title: Transcriptional profile reveals altered hepatic lipid and cholesterol metabolism in hyposulfatemic NaS1 null mice.
NaSi-1 is essential for maintaining sulfate homeostasis, and its expression is necessary for a wide range of physiological functions
Title: Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene.
1,25-(OH)(2)D(3)- and T(3)-responsive element was identified within the Nas1 promoter.
Title: Regulation of the mouse Nas1 promoter by vitamin D and thyroid hormone.
This protein is a functional sulfate transporter in the kidney and intestine
Title: Transcriptional regulation of the sodium-sulfate cotransporter NaS(i)-1 gene.
Wild-type mice showed a significant decrease in time to locate a hidden food reward over four trials after overnight fasting while Nas1-/- mice did not change their performance.
Title: Impaired memory and olfactory performance in NaSi-1 sulphate transporter deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

AI314066 (e-PCR)
- UniSTS:159488

Slc13a1 (e-PCR), detects polymorphism
- UniSTS:166230

AI987826 (e-PCR)
- UniSTS:179346

PMC263877P1 (e-PCR)
- UniSTS:272335

Slc13a1 (e-PCR), detects polymorphism
- UniSTS:547310

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables monoatomic anion:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables secondary active sulfate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:sulfate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:sulfate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:sulfate symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in sulfate transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sulfate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: solute carrier family 13 member 1

Names: Na(+)/sulfate cotransporter; renal sodium/sulfate cotransporter; solute carrier family 13 (sodium/sulphate symporters), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019481.2 → NP_062354.2 solute carrier family 13 member 1

See identical proteins and their annotated locations for NP_062354.2

Status: VALIDATED

Source sequence(s)

AK005153, AK128899, BB502145

Consensus CDS

CCDS19940.1

UniProtKB/Swiss-Prot

Q80YB5, Q8R208, Q9D2C3, Q9JHI4

Related

ENSMUSP00000031713.8, ENSMUST00000031713.9

Conserved Domains (2) summary

COG0471
Location:13 → 572

CitT; Di- and tricarboxylate transporter [Carbohydrate transport and metabolism]

cd01115
Location:38 → 566

SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

24088282..24168118 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505140.5 → XP_006505203.1 solute carrier family 13 member 1 isoform X1

Conserved Domains (1) summary

cl21473
Location:38 → 157

ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...