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Ak3 adenylate kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 56248, updated on 9-May-2024

Summary

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Official Symbol
Ak3provided by MGI
Official Full Name
adenylate kinase 3provided by MGI
Primary source
MGI:MGI:1860835
See related
Ensembl:ENSMUSG00000024782 AllianceGenome:MGI:1860835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AK-3; Ak3l; Ak3l1; Akl3l
Summary
Predicted to enable adenylate kinase activity; identical protein binding activity; and nucleoside triphosphate adenylate kinase activity. Predicted to be involved in ADP biosynthetic process and nucleoside triphosphate metabolic process. Predicted to act upstream of or within phosphorylation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AK3 (adenylate kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 99.4), liver adult (RPKM 67.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C1; 19 23.61 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (28968715..29026122, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (28995053..29048080, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA hydroxylase pseudogene Neighboring gene tektin 5 like Neighboring gene cell division cycle 37-like 1 Neighboring gene STARR-seq mESC enhancer starr_45875 Neighboring gene ribosomal protein L26 pseudogene Neighboring gene RIKEN cDNA 1700018L02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1523 Neighboring gene STARR-seq mESC enhancer starr_45878 Neighboring gene predicted gene 9895 Neighboring gene STARR-positive B cell enhancer ABC_E3249 Neighboring gene RNA terminal phosphate cyclase-like 1 Neighboring gene microRNA 101b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. Noma T, et al. Biochem J, 2001 Aug 15. PMID 11485571, Free PMC Article
  2. Biochemical diversity and evolution in the genus Mus. Bonhomme F, et al. Biochem Genet, 1984 Apr. PMID 6375655
  3. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
  4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleobase-containing compound kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside triphosphate adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside triphosphate adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, phosphate group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ADP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in AMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in AMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in AMP phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in GTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ITP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside triphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GTP:AMP phosphotransferase AK3, mitochondrial
Names
adenylate kinase 3 alpha-like 1
NP_001352000.1
NP_067274.1
XP_006527285.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365071.1 → NP_001352000.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113961
    UniProtKB/TrEMBL
    Q9D8W6
    Conserved Domains (1) summary
    pfam00406
    Location:12 → 189
    ADK; Adenylate kinase

  2. NM_021299.2 → NP_067274.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_067274.1

    Status: VALIDATED

    Source sequence(s)
    AK147060, AW457236
    Consensus CDS
    CCDS29730.1
    UniProtKB/Swiss-Prot
    Q3UDN7, Q8BGX5, Q9D7Z1, Q9DB57, Q9DBM5, Q9WTP7
    UniProtKB/TrEMBL
    Q9D8W6
    Related
    ENSMUSP00000025696.5, ENSMUST00000025696.5
    Conserved Domains (1) summary
    pfam00406
    Location:12 → 190
    ADK; Adenylate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    28968715..29026122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527222.5 → XP_006527285.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam00406
    Location:12 → 189
    ADK; Adenylate kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTP7.3 GenPept UniProtKB/Swiss-Prot:Q9WTP7

Gene LinkOut

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